Microdialysis-Assessed Adipose Tissue Metabolism, Circulating Cytokines and Outcome in Critical Illness

Microdialysis (MD) can provide continuous information about tissue composition. To assess in critically ill patients adipose tissue metabolic patterns, the relationships between metabolic patterns and blood cytokine concentration associations of adipose tissue energy metabolism and clinical outcome...

Full description

Saved in:
Bibliographic Details
Published in:Metabolites 2018-10, Vol.8 (4), p.62
Main Authors: Ilias, Ioannis, Apollonatou, Sofia, Nikitas, Nikitas, Theodorakopoulou, Maria, Vassiliou, Alice G, Kotanidou, Anastasia, Dimopoulou, Ioanna
Format: Article
Language:English
Subjects:
Adipose tissue
Blood levels
Body fat
Catheters
Cytokines
Energy metabolism
Glucose
Glycerol
Illnesses
Infections
intensive care unit
Interleukin 10
Interleukin 6
Interleukin 8
Ischemia
lactate clearance
Lactic acid
Metabolism
Metabolites
Microdialysis
Mitochondria
Patients
Pyruvic acid
Sepsis
tissue ischemia
Tumor necrosis factor-α
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c481t-c42ed78fb5cfc44beddadf2dcee914da2e9033148e1724a8a5ff707e2498a3423
cites cdi_FETCH-LOGICAL-c481t-c42ed78fb5cfc44beddadf2dcee914da2e9033148e1724a8a5ff707e2498a3423
container_end_page
container_issue 4
container_start_page 62
container_title Metabolites
container_volume 8
creator Ilias, Ioannis
Apollonatou, Sofia
Nikitas, Nikitas
Theodorakopoulou, Maria
Vassiliou, Alice G
Kotanidou, Anastasia
Dimopoulou, Ioanna
description Microdialysis (MD) can provide continuous information about tissue composition. To assess in critically ill patients adipose tissue metabolic patterns, the relationships between metabolic patterns and blood cytokine concentration associations of adipose tissue energy metabolism and clinical outcome we studied 203 mechanically ventilated general intensive care unit (ICU) patients. Upon ICU admission an MD catheter was inserted into the subcutaneous adipose tissue of the upper thigh to measure lactate (L), glucose, pyruvate (P), and glycerol. Serum concentrations of IL-10, IL-6, IL-8, and TNF-α were determined within 48 h from ICU admission. Mitochondrial dysfunction was defined as L/P ratio >30 and pyruvate ≥70 μmol/L, ischemia as L/P ratio >30 and pyruvate
doi_str_mv 10.3390/metabo8040062
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_ceb5abe406664e468b636b9440192bb9</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_ceb5abe406664e468b636b9440192bb9</doaj_id><sourcerecordid>2117821564</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-c42ed78fb5cfc44beddadf2dcee914da2e9033148e1724a8a5ff707e2498a3423</originalsourceid><addsrcrecordid>eNpdkstr3DAQh01pSUKSY65F0EsPdaOXZflSWEwfCwm5pGehx3irrWxtJTuw_32VbBqyFUIjND8-zauqrgj-zFiHr0eYtYkSc4wFfVOdUUpkTTrZvX11P60uc97isgRuWkxOqlOGGSaU4bNqc-ttis7rsM8-16ucoWyHVs7vYgZ073NeAN0-fRR8Hj-h3ie7BD37aYP6_Rx_-wky0pNDd8ts4wjIT6hPfvZWB7QOobjzRfVu0CHD5bM9r35--3rf_6hv7r6v-9VNbbkkczkpuFYOprGD5dyAc9oN1FmAjnCnKXSYMcIlkJZyLXUzDC1ugfJOasYpO6_WB66Leqt2yY867VXUXj09xLRROpXIAigLptEGOBZCcOBCGsGE6TjHpKPGdIX15cDaLWaEEsM0Jx2OoMeeyf9Sm_igBCOiVL4APj4DUvyzQJ7V6LOFEPQEccmKEtJKShrBi_TDf9JtXNJUSqVoI6ksCfJHYH1QlZ7lnGB4CYZg9TgR6mgiiv796wxe1P_6z_4CLBOz6Q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2582824948</pqid></control><display><type>article</type><title>Microdialysis-Assessed Adipose Tissue Metabolism, Circulating Cytokines and Outcome in Critical Illness</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Ilias, Ioannis ; Apollonatou, Sofia ; Nikitas, Nikitas ; Theodorakopoulou, Maria ; Vassiliou, Alice G ; Kotanidou, Anastasia ; Dimopoulou, Ioanna</creator><creatorcontrib>Ilias, Ioannis ; Apollonatou, Sofia ; Nikitas, Nikitas ; Theodorakopoulou, Maria ; Vassiliou, Alice G ; Kotanidou, Anastasia ; Dimopoulou, Ioanna</creatorcontrib><description>Microdialysis (MD) can provide continuous information about tissue composition. To assess in critically ill patients adipose tissue metabolic patterns, the relationships between metabolic patterns and blood cytokine concentration associations of adipose tissue energy metabolism and clinical outcome we studied 203 mechanically ventilated general intensive care unit (ICU) patients. Upon ICU admission an MD catheter was inserted into the subcutaneous adipose tissue of the upper thigh to measure lactate (L), glucose, pyruvate (P), and glycerol. Serum concentrations of IL-10, IL-6, IL-8, and TNF-α were determined within 48 h from ICU admission. Mitochondrial dysfunction was defined as L/P ratio &gt;30 and pyruvate ≥70 μmol/L, ischemia as L/P ratio &gt;30 and pyruvate &lt;70 μmol/L and no ischemia/no mitochondrial dysfunction (i.e. aerobic metabolism) was as L/P ratio ≤30. Metabolism was aerobic in 74% of patients. In 13% of patients there was biochemical evidence of ischemia and in 13% of patients of mitochondrial dysfunction. Mitochondrial dysfunction was associated with poor outcome. In conclusion, MD showed that about two thirds of critically ill patients have normal aerobic adipose tissue metabolism. Mitochondrial dysfunction was not common but was associated with poor outcome. Identifying subgroups of critically ill patients is crucial as different treatment strategies may improve survival.</description><identifier>ISSN: 2218-1989</identifier><identifier>EISSN: 2218-1989</identifier><identifier>DOI: 10.3390/metabo8040062</identifier><identifier>PMID: 30301230</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adipose tissue ; Blood levels ; Body fat ; Catheters ; Cytokines ; Energy metabolism ; Glucose ; Glycerol ; Illnesses ; Infections ; intensive care unit ; Interleukin 10 ; Interleukin 6 ; Interleukin 8 ; Ischemia ; lactate clearance ; Lactic acid ; Metabolism ; Metabolites ; Microdialysis ; Mitochondria ; Patients ; Pyruvic acid ; Sepsis ; tissue ischemia ; Tumor necrosis factor-α</subject><ispartof>Metabolites, 2018-10, Vol.8 (4), p.62</ispartof><rights>2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-c42ed78fb5cfc44beddadf2dcee914da2e9033148e1724a8a5ff707e2498a3423</citedby><cites>FETCH-LOGICAL-c481t-c42ed78fb5cfc44beddadf2dcee914da2e9033148e1724a8a5ff707e2498a3423</cites><orcidid>0000-0001-5718-7441</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2582824948/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2582824948?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30301230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ilias, Ioannis</creatorcontrib><creatorcontrib>Apollonatou, Sofia</creatorcontrib><creatorcontrib>Nikitas, Nikitas</creatorcontrib><creatorcontrib>Theodorakopoulou, Maria</creatorcontrib><creatorcontrib>Vassiliou, Alice G</creatorcontrib><creatorcontrib>Kotanidou, Anastasia</creatorcontrib><creatorcontrib>Dimopoulou, Ioanna</creatorcontrib><title>Microdialysis-Assessed Adipose Tissue Metabolism, Circulating Cytokines and Outcome in Critical Illness</title><title>Metabolites</title><addtitle>Metabolites</addtitle><description>Microdialysis (MD) can provide continuous information about tissue composition. To assess in critically ill patients adipose tissue metabolic patterns, the relationships between metabolic patterns and blood cytokine concentration associations of adipose tissue energy metabolism and clinical outcome we studied 203 mechanically ventilated general intensive care unit (ICU) patients. Upon ICU admission an MD catheter was inserted into the subcutaneous adipose tissue of the upper thigh to measure lactate (L), glucose, pyruvate (P), and glycerol. Serum concentrations of IL-10, IL-6, IL-8, and TNF-α were determined within 48 h from ICU admission. Mitochondrial dysfunction was defined as L/P ratio &gt;30 and pyruvate ≥70 μmol/L, ischemia as L/P ratio &gt;30 and pyruvate &lt;70 μmol/L and no ischemia/no mitochondrial dysfunction (i.e. aerobic metabolism) was as L/P ratio ≤30. Metabolism was aerobic in 74% of patients. In 13% of patients there was biochemical evidence of ischemia and in 13% of patients of mitochondrial dysfunction. Mitochondrial dysfunction was associated with poor outcome. In conclusion, MD showed that about two thirds of critically ill patients have normal aerobic adipose tissue metabolism. Mitochondrial dysfunction was not common but was associated with poor outcome. Identifying subgroups of critically ill patients is crucial as different treatment strategies may improve survival.</description><subject>Adipose tissue</subject><subject>Blood levels</subject><subject>Body fat</subject><subject>Catheters</subject><subject>Cytokines</subject><subject>Energy metabolism</subject><subject>Glucose</subject><subject>Glycerol</subject><subject>Illnesses</subject><subject>Infections</subject><subject>intensive care unit</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Interleukin 8</subject><subject>Ischemia</subject><subject>lactate clearance</subject><subject>Lactic acid</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Microdialysis</subject><subject>Mitochondria</subject><subject>Patients</subject><subject>Pyruvic acid</subject><subject>Sepsis</subject><subject>tissue ischemia</subject><subject>Tumor necrosis factor-α</subject><issn>2218-1989</issn><issn>2218-1989</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkstr3DAQh01pSUKSY65F0EsPdaOXZflSWEwfCwm5pGehx3irrWxtJTuw_32VbBqyFUIjND8-zauqrgj-zFiHr0eYtYkSc4wFfVOdUUpkTTrZvX11P60uc97isgRuWkxOqlOGGSaU4bNqc-ttis7rsM8-16ucoWyHVs7vYgZ073NeAN0-fRR8Hj-h3ie7BD37aYP6_Rx_-wky0pNDd8ts4wjIT6hPfvZWB7QOobjzRfVu0CHD5bM9r35--3rf_6hv7r6v-9VNbbkkczkpuFYOprGD5dyAc9oN1FmAjnCnKXSYMcIlkJZyLXUzDC1ugfJOasYpO6_WB66Leqt2yY867VXUXj09xLRROpXIAigLptEGOBZCcOBCGsGE6TjHpKPGdIX15cDaLWaEEsM0Jx2OoMeeyf9Sm_igBCOiVL4APj4DUvyzQJ7V6LOFEPQEccmKEtJKShrBi_TDf9JtXNJUSqVoI6ksCfJHYH1QlZ7lnGB4CYZg9TgR6mgiiv796wxe1P_6z_4CLBOz6Q</recordid><startdate>20181006</startdate><enddate>20181006</enddate><creator>Ilias, Ioannis</creator><creator>Apollonatou, Sofia</creator><creator>Nikitas, Nikitas</creator><creator>Theodorakopoulou, Maria</creator><creator>Vassiliou, Alice G</creator><creator>Kotanidou, Anastasia</creator><creator>Dimopoulou, Ioanna</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5718-7441</orcidid></search><sort><creationdate>20181006</creationdate><title>Microdialysis-Assessed Adipose Tissue Metabolism, Circulating Cytokines and Outcome in Critical Illness</title><author>Ilias, Ioannis ; Apollonatou, Sofia ; Nikitas, Nikitas ; Theodorakopoulou, Maria ; Vassiliou, Alice G ; Kotanidou, Anastasia ; Dimopoulou, Ioanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-c42ed78fb5cfc44beddadf2dcee914da2e9033148e1724a8a5ff707e2498a3423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipose tissue</topic><topic>Blood levels</topic><topic>Body fat</topic><topic>Catheters</topic><topic>Cytokines</topic><topic>Energy metabolism</topic><topic>Glucose</topic><topic>Glycerol</topic><topic>Illnesses</topic><topic>Infections</topic><topic>intensive care unit</topic><topic>Interleukin 10</topic><topic>Interleukin 6</topic><topic>Interleukin 8</topic><topic>Ischemia</topic><topic>lactate clearance</topic><topic>Lactic acid</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Microdialysis</topic><topic>Mitochondria</topic><topic>Patients</topic><topic>Pyruvic acid</topic><topic>Sepsis</topic><topic>tissue ischemia</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ilias, Ioannis</creatorcontrib><creatorcontrib>Apollonatou, Sofia</creatorcontrib><creatorcontrib>Nikitas, Nikitas</creatorcontrib><creatorcontrib>Theodorakopoulou, Maria</creatorcontrib><creatorcontrib>Vassiliou, Alice G</creatorcontrib><creatorcontrib>Kotanidou, Anastasia</creatorcontrib><creatorcontrib>Dimopoulou, Ioanna</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Metabolites</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ilias, Ioannis</au><au>Apollonatou, Sofia</au><au>Nikitas, Nikitas</au><au>Theodorakopoulou, Maria</au><au>Vassiliou, Alice G</au><au>Kotanidou, Anastasia</au><au>Dimopoulou, Ioanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microdialysis-Assessed Adipose Tissue Metabolism, Circulating Cytokines and Outcome in Critical Illness</atitle><jtitle>Metabolites</jtitle><addtitle>Metabolites</addtitle><date>2018-10-06</date><risdate>2018</risdate><volume>8</volume><issue>4</issue><spage>62</spage><pages>62-</pages><issn>2218-1989</issn><eissn>2218-1989</eissn><abstract>Microdialysis (MD) can provide continuous information about tissue composition. To assess in critically ill patients adipose tissue metabolic patterns, the relationships between metabolic patterns and blood cytokine concentration associations of adipose tissue energy metabolism and clinical outcome we studied 203 mechanically ventilated general intensive care unit (ICU) patients. Upon ICU admission an MD catheter was inserted into the subcutaneous adipose tissue of the upper thigh to measure lactate (L), glucose, pyruvate (P), and glycerol. Serum concentrations of IL-10, IL-6, IL-8, and TNF-α were determined within 48 h from ICU admission. Mitochondrial dysfunction was defined as L/P ratio &gt;30 and pyruvate ≥70 μmol/L, ischemia as L/P ratio &gt;30 and pyruvate &lt;70 μmol/L and no ischemia/no mitochondrial dysfunction (i.e. aerobic metabolism) was as L/P ratio ≤30. Metabolism was aerobic in 74% of patients. In 13% of patients there was biochemical evidence of ischemia and in 13% of patients of mitochondrial dysfunction. Mitochondrial dysfunction was associated with poor outcome. In conclusion, MD showed that about two thirds of critically ill patients have normal aerobic adipose tissue metabolism. Mitochondrial dysfunction was not common but was associated with poor outcome. Identifying subgroups of critically ill patients is crucial as different treatment strategies may improve survival.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30301230</pmid><doi>10.3390/metabo8040062</doi><orcidid>https://orcid.org/0000-0001-5718-7441</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2218-1989
ispartof Metabolites, 2018-10, Vol.8 (4), p.62
issn 2218-1989
2218-1989
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_ceb5abe406664e468b636b9440192bb9
source Publicly Available Content Database; PubMed Central
subjects Adipose tissue
Blood levels
Body fat
Catheters
Cytokines
Energy metabolism
Glucose
Glycerol
Illnesses
Infections
intensive care unit
Interleukin 10
Interleukin 6
Interleukin 8
Ischemia
lactate clearance
Lactic acid
Metabolism
Metabolites
Microdialysis
Mitochondria
Patients
Pyruvic acid
Sepsis
tissue ischemia
Tumor necrosis factor-α
title Microdialysis-Assessed Adipose Tissue Metabolism, Circulating Cytokines and Outcome in Critical Illness
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T13%3A19%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microdialysis-Assessed%20Adipose%20Tissue%20Metabolism,%20Circulating%20Cytokines%20and%20Outcome%20in%20Critical%20Illness&rft.jtitle=Metabolites&rft.au=Ilias,%20Ioannis&rft.date=2018-10-06&rft.volume=8&rft.issue=4&rft.spage=62&rft.pages=62-&rft.issn=2218-1989&rft.eissn=2218-1989&rft_id=info:doi/10.3390/metabo8040062&rft_dat=%3Cproquest_doaj_%3E2117821564%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c481t-c42ed78fb5cfc44beddadf2dcee914da2e9033148e1724a8a5ff707e2498a3423%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2582824948&rft_id=info:pmid/30301230&rfr_iscdi=true