Editorial: Dopaminergic control of experience encoding, memory and cognition

D1/D5 and D2-like receptors, which activate distinct signaling pathways and modulate synaptic plasticity and neuronal activity. [...]dopamine-based treatments often disrupt the balance of the system and cause unwanted side effects in patients. In line with this idea, Hagena et al. demonstrate that t...

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Bibliographic Details
Published in:Frontiers in behavioral neuroscience 2023-07, Vol.17, p.1230576-1230576
Main Authors: Haubrich, Josué, Hagena, Hardy, Tsanov, Marian, Manahan-Vaughan, Denise
Format: Article
Language:English
Subjects:
amygdala
Behavioral Neuroscience
Brain research
Clinical trials
Cognition
Cognition & reasoning
Conflicts of interest
Dopamine
Dopamine D1 receptors
Dopamine D2 receptors
Dopamine D5 receptors
dopamine receptors
Hippocampal plasticity
Hippocampus
learning and memory
Memory
Mental disorders
Motivation
Neurosciences
Parkinson's disease
prefrontal cortex
Rodents
Sleep
Synaptic plasticity
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Summary:D1/D5 and D2-like receptors, which activate distinct signaling pathways and modulate synaptic plasticity and neuronal activity. [...]dopamine-based treatments often disrupt the balance of the system and cause unwanted side effects in patients. In line with this idea, Hagena et al. demonstrate that two mouse strains (CaOlaHsd and C57Bl6) have different patterns of D1/5R expression in the hippocampus and found that such altered balance results in changes in dopaminergic-dependent synaptic plasticity. [...]differences in D1/D5R expression may explain, in part, strain-dependent variations in synaptic plasticity in the murine hippocampus. [...]this collection of articles highlights the crucial role of dopaminergic modulation in different aspects of synaptic plasticity and cognition.
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2023.1230576