Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999-2018)

Research on the association between blood lead (Pb) and lipid biomarkers have yielded inconsistent results, and epidemiological studies on blood Pb levels and hyperlipidemia are scarce. The present study aimed to examine the association between blood Pb levels and hyperlipidemia in adults from the N...

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Published in:Frontiers in public health 2022-09, Vol.10, p.981749-981749
Main Authors: Zhang, Yangchang, Liu, Weiwei, Zhang, Wei, Cheng, Rui, Tan, Andi, Shen, Shisi, Xiong, Yang, Zhao, Limei, Lei, Xun
Format: Article
Language:English
Subjects:
Adult
adults
Biomarkers
blood
Cholesterol
Electrolytes
environment pollution
Female
Humans
hyperlipidemia
Lead
NHANES
Nutrition Surveys
Pregnancy
Public Health
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Summary:Research on the association between blood lead (Pb) and lipid biomarkers have yielded inconsistent results, and epidemiological studies on blood Pb levels and hyperlipidemia are scarce. The present study aimed to examine the association between blood Pb levels and hyperlipidemia in adults from the National Health and Nutrition Examination Survey (NHANES). A total of 43,196 participants in the NHANES from 1999 to 2018 were included in the final analysis. Hyperlipidemia was determined based on the National Cholesterol Education Program guidelines. Blood Pb levels were assessed using inductively-coupled plasma mass spectrometry. Weighted multivariable logistic regression analysis and subgroup analysis were conducted to determine the correlation between blood Pb levels and hyperlipidemia. In the multivariable logistic regression model, high blood Pb levels were significantly associated with hyperlipidemia after adjusting for confounders (OR 1.41; 95%CI: 1.18-1.67). Furthermore, elevated blood Pb levels were associated with an increased risk of hyperlipidemia across the four quartile (Q) groups (Q1: OR 1.00; Q2: OR 1.16 [95%CI: 1.04-1.29]; Q3: OR 1.39 [95%CI: 1.21-1.59]; and Q4: OR 1.33 [95%CI: 1.15-1.54]; for trend
ISSN:2296-2565
2296-2565
DOI:10.3389/fpubh.2022.981749