Mutated KIT Tyrosine Kinase as a Novel Molecular Target in Acute Myeloid Leukemia

• Published in: International journal of molecular sciences 2022-04, Vol.23 (9), p.4694
• Main Authors: Katagiri, Seiichiro, Chi, SungGi, Minami, Yosuke, Fukushima, Kentaro, Shibayama, Hirohiko, Hosono, Naoko, Yamauchi, Takahiro, Morishita, Takanobu, Kondo, Takeshi, Yanada, Masamitsu, Yamamoto, Kazuhito, Kuroda, Junya, Usuki, Kensuke, Akahane, Daigo, Gotoh, Akihiko
• Format: Article
• Language: English
• Subjects: Acute myeloid leukemia; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Cell signaling; Clinical outcomes; Gastrointestinal cancer; Genes; genome profiling; Genomes; Heat shock proteins; HSP90 inhibitor; Hsp90 protein; Humans; Immunoglobulins; Kinases; KIT mutation; Leukemia; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - pathology; Melanoma; Mutation; Next-generation sequencing; Patients; Phosphorylation; Protein-tyrosine kinase receptors; Protein-Tyrosine Kinases - metabolism; Proto-Oncogene Proteins c-kit - genetics; Proto-Oncogene Proteins c-kit - metabolism; Review; RUNX1-RUNX1T1; Signal Transduction; Stem cells; Tumors; Tyrosine
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23094694

KIT is a type-III receptor tyrosine kinase that contributes to cell signaling in various cells. Since KIT is activated by overexpression or mutation and plays an important role in the development of some cancers, such as gastrointestinal stromal tumors and mast cell disease, molecular therapies targeting mutations are being developed. In acute myeloid leukemia (AML), genome profiling via next-generation sequencing has shown that several genes that are mutated in patients with AML impact patients' prognosis. Moreover, it was suggested that precision-medicine-based treatment using genomic data will improve treatment outcomes for AML patients. This paper presents (1) previous studies regarding the role of mutations in AML, (2) the data in AML with mutations from the HM-SCREEN-Japan-01 study, a genome profiling study for patients newly diagnosed with AML who are unsuitable for the standard first-line treatment (unfit) or have relapsed/refractory AML, and (3) new therapies targeting mutations, such as tyrosine kinase inhibitors and heat shock protein 90 inhibitors. In this era when genome profiling via next-generation sequencing is becoming more common, mutations are attractive novel molecular targets in AML.