Changes in plasma fatty acids profile in hyperketonemic ewes during early lactation: a preliminary study

• Published in: Scientific reports 2022-10, Vol.12 (1), p.17017-17017, Article 17017
• Main Authors: Lisuzzo, Anastasia, Fiore, Filippo, Harvatine, Kevin, Mazzotta, Elisa, Berlanda, Michele, Spissu, Nicoletta, Badon, Tamara, Contiero, Barbara, Moscati, Livia, Fiore, Enrico
• Format: Article
• Language: English
• Subjects: 3-Hydroxybutyric Acid; 631/601/1737; 692/53/2421; Adipose tissue; Animals; Cross-Sectional Studies; Energy balance; Experimental design; Fatty acids; Fatty Acids - metabolism; Fatty Acids, Nonesterified - metabolism; Female; Gas chromatography; Humanities and Social Sciences; Immune response; Inflammation; Lactation; Lactation - physiology; Lipid metabolism; Milk - chemistry; multidisciplinary; Observational studies; Parity; Plasma; Pregnancy; Science; Science (multidisciplinary); Sheep; Stearic acid; Stearic Acids - metabolism; Variance analysis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-21088-5

The transition from late pregnancy to early lactation is characterized by marked changes in energy balance of dairy ruminants. The mobilization of adipose tissue led to an increase in plasma non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHB). The aim of this study was to analyze the total plasma fatty acids of healthy and hyperketonemic dairy ewes in early lactation through gas chromatography (GC) to evaluate metabolic alterations. An observational study was used with a cross-sectional experimental design. Forty-six Sarda dairy ewes were enrolled in the immediate post-partum (7 ± 3 days in milk) and divided into two groups according to serum BHB concentration: non-hyperketonemic group (n = 28; BHB