Possible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia

This study investigated the possible association between common and potentially functional polymorphisms of antioxidant enzymes and metabolic abnormalities in patients with schizophrenia. The possible associations of the glutathione S-transferase (GST) M1 null and GSTT1 null genotypes, and the super...

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Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2013-01, Vol.9 (default), p.1683-1698
Main Authors: Saruwatari, Junji, Yasui-Furukori, Norio, Kamihashi, Ryoko, Yoshimori, Yuki, Oniki, Kentaro, Tsuchimine, Shoko, Noai, Madoka, Sato, Yasushi, Nakagami, Taku, Sugawara, Norio, Saito, Manabu, Fujii, Akira, Kajiwara, Ayami, Mihara, Shuichi, Ogata, Yasuhiro, Kaneko, Sunao, Nakagawa, Kazuko
Format: Article
Language:English
Subjects:
Antioxidants
Genetic aspects
Genetic polymorphisms
Genotype & phenotype
glutathione S-transferase
Glutathione transferase
Health risk assessment
Metabolic diseases
Metabolic syndrome
Metabolism
Original Research
Oxidative stress
Polymorphism
Risk factors
Schizophrenia
superoxide dismutase 2
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Summary:This study investigated the possible association between common and potentially functional polymorphisms of antioxidant enzymes and metabolic abnormalities in patients with schizophrenia. The possible associations of the glutathione S-transferase (GST) M1 null and GSTT1 null genotypes, and the superoxide dismutase 2 (SOD2) Val16Ala polymorphism with the risks of being overweight and having metabolic syndrome were examined using a logistic regression analysis in 154 schizophrenic Japanese patients and 203 controls. Among smokers with schizophrenia, the risks of being overweight and having decreased high-density lipoprotein cholesterol were significantly higher in those with the GSTM1 null genotype than in those with the present genotype (odds ratio 3.20 and 3.15, P=0.03 and P=0.04, respectively), while among nonsmokers with schizophrenia, the risk of an abnormal waist circumference was lower in those with the GSTM1 null genotype (odds ratio 0.34, P=0.04). The risk of a decreased high-density lipoprotein cholesterol level was significantly higher in patients with the combined GSTM1 null and GSTT1 present genotypes than in those with the present genotypes of both genes (odds ratio 3.60, P
ISSN:1176-6328
1176-6328
1178-2021
DOI:10.2147/NDT.S52585