Artemisiae argyi Water Extract Alleviates Obesity-Induced Metabolic Disorder

is a well-known traditional herbal medicine used in East Asia. Although the antibacterial and anti-inflammatory effects of have been reported, its efficacy in improving obesity has not been yet evaluated. In this study, mice were fed a normal diet (AIN-93), a high-fat diet (HFD, 60% of kcal from fat...

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Published in:Current issues in molecular biology 2022-12, Vol.44 (12), p.6158-6171
Main Authors: Han, Youngji, Park, Hae-Jin, Hong, Min-Kyeong, Shin, Mi-Rae, Roh, Seong-Soo, Kwon, Eun-Young
Format: Article
Language:English
Subjects:
Artemisiae argyi
herbal medicine
natural product
obesity
type 2 diabetes mellitus
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Summary:is a well-known traditional herbal medicine used in East Asia. Although the antibacterial and anti-inflammatory effects of have been reported, its efficacy in improving obesity has not been yet evaluated. In this study, mice were fed a normal diet (AIN-93), a high-fat diet (HFD, 60% of kcal from fat), and an HFD with 0.1% of water extract for 16 weeks. The body weight and body fat in fed mice significantly decreased via upregulation of the mRNA expression of fatty acid oxidation-related genes, with a simultaneous decrease in plasma lipid content and leptin levels. water extract also ameliorated hepatic steatosis by restricting lipogenesis via lowering the activities of fatty acid synthase and phosphatidic acid phosphatase. Consistently, hepatic histological analysis indicated that water extract decreased hepatic lipid accumulation in accordance with the hepatic H, E and Oil Red O-stained area. Additionally, ameliorated the impaired glucose homeostasis by increasing the mRNA expression of AMP-activated kinase and glycolysis-related genes. In conclusion, our results indicate that can be used to treat obesity-related metabolic conditions.
ISSN:1467-3045
1467-3037
1467-3045
DOI:10.3390/cimb44120420