Modeling of brain tumors using in vitro, in vivo, and microfluidic models: A review of the current developments

Brain cancers are some of the most complex diseases to treat, despite the numerous advances science has made in cancer chemotherapy and research. One of the key obstacles to identifying potential cures for this disease is the difficulty in emulating the complexity of the brain and the surrounding mi...

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Bibliographic Details
Published in:Heliyon 2024-05, Vol.10 (10), p.e31402-e31402, Article e31402
Main Authors: Raju R, Richu, AlSawaftah, Nour M., Husseini, Ghaleb A.
Format: Article
Language:English
Subjects:
Brain cancer
In vitro
In vivo
Microfluidics
Review
Tumor microenvironment
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Summary:Brain cancers are some of the most complex diseases to treat, despite the numerous advances science has made in cancer chemotherapy and research. One of the key obstacles to identifying potential cures for this disease is the difficulty in emulating the complexity of the brain and the surrounding microenvironment to understand potential therapeutic approaches. This paper discusses some of the most important in vitro, in vivo, and microfluidic brain tumor models that aim to address these challenges.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e31402