Clinical presentation and survival of smear-positive pulmonary tuberculosis patients of a university general hospital in a developing country

From January 1995 to August 1997 we evaluated prospectively the clinical presentation, laboratory findings and short-term survival of smear-positive pulmonary tuberculosis (TB) patients who sought care at our hospital. After providing informed, written consent, the patients were interviewed and labo...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2002-12, Vol.97 (8), p.1225-1230
Main Authors: Carvalho, Anna C C, Nunes, Zoelete B, Martins, Marneili, Araújo, Rodrigo O C, Comelli, Mario, Marinoni, Alessandra, Kritski, Afrânio L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
AIDS-Related Opportunistic Infections - complications
AIDS-Related Opportunistic Infections - mortality
Brazil - epidemiology
Developing Countries
Epidemiologic Studies
Female
HIV infection
Hospitals, General
Hospitals, University
Humans
Male
Middle Aged
PARASITOLOGY
survival
TROPICAL MEDICINE
tuberculosis
Tuberculosis, Pulmonary - complications
Tuberculosis, Pulmonary - mortality
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Summary:From January 1995 to August 1997 we evaluated prospectively the clinical presentation, laboratory findings and short-term survival of smear-positive pulmonary tuberculosis (TB) patients who sought care at our hospital. After providing informed, written consent, the patients were interviewed and laboratory tests were performed. Information about survivorship and death was collected through September 1998. Eighty-six smear-positive pulmonary TB patients were enrolled; 26.7% were HIV-seropositive. Seventeen HIV-seronegative pulmonary TB patients (19.8%) presented chronic diseases in addition to TB. In the multiple logistic regression analysis a CD4+ cell count or = 50 years were independently associated with decreased survival. Among HIV-seronegative persons, the presence of an additional disease increased the risk of death of almost six-fold. Use of antiretroviral drugs was associated with a lower risk of death among HIV-seropositive smear-positive pulmonary TB patients (RH = 0.32, 95% CI 0.10-0.92). In our study smear-positive pulmonary TB patients had a low short-term survival rate that was strongly associated with HIV infection, age and co-morbidities. Therapy with antiretroviral drugs reduced the short-term risk of death among HIV-seropositive patients after TB diagnosis.
ISSN:0074-0276
1678-8060
0074-0276
1678-8060
DOI:10.1590/S0074-02762002000800027