Efficacy of Topical 5% Acyclovir-1% Hydrocortisone Cream (ME-609) for Treatment of Herpes Labialis: a systematic review

We performed a systematic review with the objective of verifying the efficacy of topical use 5% Acyclovir-1% Hydrocortisone cream compared to the placebo group for herpes simplex labialis treatment. We performed a literature search using MEDLINE, Embase, BIOSIS, LILACS, Scopus, Grey literature, the...

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Bibliographic Details
Published in:Anais da Academia Brasileira de Ciências 2015-08, Vol.87 (2 Suppl), p.1415-1420
Main Authors: Rosa, Maria Inês da, Souza, Suéli L, Farias, Bruna F de, Pires, Patrícia D S, Dondossola, Eduardo R, dos Reis, Maria Eduarda F
Format: Article
Language:English
Subjects:
aciclovir
Acyclovir - administration & dosage
Administration, Topical
Anti-Inflammatory Agents - administration & dosage
Antiviral Agents - administration & dosage
Drug Combinations
herpes labial
Herpes Labialis - drug therapy
hidrocortisona
Humans
Hydrocortisone - administration & dosage
ME-609
MULTIDISCIPLINARY SCIENCES
Randomized Controlled Trials as Topic
Revisão Sistemática
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Summary:We performed a systematic review with the objective of verifying the efficacy of topical use 5% Acyclovir-1% Hydrocortisone cream compared to the placebo group for herpes simplex labialis treatment. We performed a literature search using MEDLINE, Embase, BIOSIS, LILACS, Scopus, Grey literature, the Cochrane Central Register of Controlled Trials, the ISI Web of Science and IBECS from 1990 to June 2014. We reported the outcomes using relative risk (RR) with 95% confidence intervals. The literature search yielded 180 potentially relevant publications. Reviews of the reference lists yielded two further citations. Among these papers, two were considered eligible for inclusion in this review. Both trials included 1,213 patients. A meta-analysis of these studies showed a RR = 0.77, (95% CI 0.70-0.86; p
ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765201520140701