Antiperiodontitis Effects of Siegesbeckia glabrescens In Vitro

is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of on periodontitis are unknown. In this study, we determined the effects of an 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), ant...

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Bibliographic Details
Published in:Antioxidants 2023-02, Vol.12 (2), p.471
Main Authors: Bellere, Arce Defeo, Yu, Duna, Oh, Sarang, Kim, Myeongju, Jung, Jeyong, Fang, Minzhe, Zheng, Shengdao, Yi, Tae-Hoo
Format: Article
Language:English
Subjects:
Antimicrobial agents
Antioxidants
Arthritis
Bacteria
Biofilms
Dental caries
Disease
Ethanol
Fibroblasts
Inflammatory diseases
Lipopolysaccharides
Matrix metalloproteinase
Metalloproteinase
Oral cancer
Oral hygiene
Pathogens
Periodontal ligament
Periodontitis
Porphyromonas gingivalis
Roadsides
Siegesbeckia glabrescens
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Summary:is generally grown in fields or roadsides in Korea and used for the treatment of inflammatory diseases. The effects of on periodontitis are unknown. In this study, we determined the effects of an 30% EtOH extract (SGE) on periodontitis and analyzed the antioxidant activity (DPPH, ABTS, and SOD), antimicrobial (disc diffusion, MIC, and MBC), inhibition of GTFs, biofilm formation, and the anti-inflammation of lipopolysaccharide from (LPS-PG)-induced primary equine periodontal ligament fibroblasts (PDLFs). We report that SGE increased DPPH, ABTS, and SOD antioxidant activities in a dose-dependent manner. SGE caused a clear zone with a diameter of 15 mm or more against periodontal pathogens. SGE (2.50 mg/mL) inhibited GTFs and biofilm by 89.07% and 85.40%, respectively. SGE treatment (100 µg/mL) also significantly decreased the secretion of inflammatory mediators in sensitized PDLF, including cytokines and matrix metalloproteinase (MMP)-3, -8, -9, and -13. Overall, we confirmed that SGE had excellent antioxidant, antimicrobial, and anti-inflammatory effects against periodontal pathogens. These results suggest that it has the potential to develop as a prophylactic agent for periodontitis.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox12020471