Metals and Neurodegeneration

Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function...

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Bibliographic Details
Published in:F1000 research 2016, Vol.5, p.366
Main Authors: Chen, Pan, Miah, Mahfuzur Rahman, Aschner, Michael
Format: Article
Language:English
Subjects:
Cognitive Neurology & Dementia
Cognitive Neuroscience
Control of Gene Expression
Membranes & Sorting
Motor Systems
Movement Disorders
Neurobiology of Disease & Regeneration
Neurodevelopment
Neurogenetics
Neuronal & Glial Cell Biology
Parkinson's disease
Review
Toxicology
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Summary:Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes. Damage caused by metal accumulation may result in permanent injuries, including severe neurological disorders. Epidemiological and clinical studies have shown a strong correlation between aberrant metal exposure and a number of neurological diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, autism spectrum disorders, Guillain-Barré disease, Gulf War syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and Wilson's disease. Here, we briefly survey the literature relating to the role of metals in neurodegeneration.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.7431.1