Roles of Long Non-coding RNAs in the Development of Aging-Related Neurodegenerative Diseases

Aging-related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are gradually becoming the primary burden of society and cause significant health-care concerns. Aging is a criti...

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Bibliographic Details
Published in:Frontiers in molecular neuroscience 2022-03, Vol.15, p.844193-844193
Main Authors: Ni, Yu-Qing, Xu, Hui, Liu, You-Shuo
Format: Article
Language:English
Subjects:
ageing
Aging
Alzheimer's disease
Amyotrophic lateral sclerosis
Huntington's disease
Huntingtons disease
long non-coding RNAs
Mitochondria
Mitochondrial DNA
Movement disorders
Mutation
Neurodegeneration
Neurodegenerative diseases
Neuroscience
Non-coding RNA
Oxidation
Oxidative stress
Parkinson's disease
Risk factors
Signal transduction
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Summary:Aging-related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are gradually becoming the primary burden of society and cause significant health-care concerns. Aging is a critical independent risk factor for neurodegenerative diseases. The pathological alterations of neurodegenerative diseases are tightly associated with mitochondrial dysfunction, inflammation, and oxidative stress, which in turn stimulates the further progression of neurodegenerative diseases. Given the potential research value, lncRNAs have attracted considerable attention. LncRNAs play complex and dynamic roles in multiple signal transduction axis of neurodegeneration. Emerging evidence indicates that lncRNAs exert crucial regulatory effects in the initiation and development of aging-related neurodegenerative diseases. This review compiles the underlying pathological mechanisms of aging and related neurodegenerative diseases. Besides, we discuss the roles of lncRNAs in aging. In addition, the crosstalk and network of lncRNAs in neurodegenerative diseases are also explored.
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2022.844193