3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice

Polygalae Radix is an important medicinal plant that is widely used in most of Africa. 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix. Until now, the mechanisms involved in the anti-seizure property of TMCA are still unclear. We examined the anti-seizure effect of...

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Bibliographic Details
Published in:Journal of pharmacological sciences 2016-05, Vol.131 (1), p.1-5
Main Authors: Chen, Chang-Yuan, Wei, Xu-Dong, Chen, Chang-Rui
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Cinnamates - pharmacology
Cinnamates - therapeutic use
Electroshock
Flumazenil
Flumazenil - pharmacology
GABA Antagonists - pharmacology
GABA receptor
Male
Mice
Pentylenetetrazol
Pentylenetetrazole
Plant Roots
Polygala
Receptors, GABA-A - metabolism
Seizure
Seizures - drug therapy
Seizures - etiology
Seizures - metabolism
TMCA
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Summary:Polygalae Radix is an important medicinal plant that is widely used in most of Africa. 3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix. Until now, the mechanisms involved in the anti-seizure property of TMCA are still unclear. We examined the anti-seizure effect of TMCA. TMCA administered at doses of 5, 10 and 20 mg/kg and evaluated anti-seizure effects by maximal electroshock (MES) and pentylenetetrazol (PTZ) models in mice. TMCA administered at doses of 10 and 20 mg/kg significantly reduced the incidence of MES-induced tonic hindlimb extension (THE). TMCA significantly delayed the onset of myoclonic jerks (MJ), and decreased the seizure severity and mortality compared with the vehicle-treated animals in PTZ seizure model. TMCA 10 and 20 mg/kg treated groups also did not determined generalized clonic seizures (GCS). Pretreatment with a GABAA/benzodiazepine (BZ) receptor antagonist flumazenil blocked the anti-seizure effects of TMCA. These data support the further investigation of TMCA as a GABAA/BZ receptor agonist for anti-seizure therapy.
ISSN:1347-8613
1347-8648
DOI:10.1016/j.jphs.2015.07.021