The Combination of Tamarindus indica and Coenzyme Q10 can be a Potential Therapy Preference to Attenuate Cadmium-Induced Hepatorenal Injury

Cadmium (Cd) is a hazardous environmental pollutant that menaces human and animal health and induces serious adverse effects in various organs, particularly the liver and kidneys. Thus, the current study was designed to look into the possible mechanisms behind the ameliorative activities of Tamarind...

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Published in:Frontiers in pharmacology 2022-08, Vol.13, p.954030-954030
Main Authors: Abdelnaby, Amany, Abdel-Aleem, Nabila, Mansour, Ayman, Abdelkader, Afaf, Ibrahim, Amany N., Sorour, Safwa M., Elgendy, Enas, Bayoumi, Heba, Abdelrahman, Shaymaa M., Ibrahim, Samah F., Alsaati, Ilhaam, Abdeen, Ahmed
Format: Article
Language:English
Subjects:
antioxidants
cadmium
coenzyme Q10
hepatorenal damage
oxidative stress
Pharmacology
Tamarindus indica
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Summary:Cadmium (Cd) is a hazardous environmental pollutant that menaces human and animal health and induces serious adverse effects in various organs, particularly the liver and kidneys. Thus, the current study was designed to look into the possible mechanisms behind the ameliorative activities of Tamarindus indica (TM) and coenzyme Q10 (CoQ) combined therapy toward Cd-inflicted tissue injury. Male Wistar rats were categorized into seven groups: Control (received saline only); TM (50 mg/kg); CoQ (40 mg/kg); Cd (2 mg/kg); (Cd + TM); (Cd + CoQ); and (Cd + TM + CoQ). All the treatments were employed once daily via oral gavage for 28 consecutive days. The results revealed that Cd exposure considerably induced liver and kidney damage, evidenced by enhancement of liver and kidney function tests. In addition, Cd intoxication could provoke oxidative stress evidenced by markedly decreased glutathione (GSH) content and catalase (CAT) activity alongside a substantial increase in malondialdehyde (MDA) concentrations in the hepatic and renal tissues. Besides, disrupted protein and lipid metabolism were noticed. Unambiguously, TM or CoQ supplementation alleviated Cd-induced hepatorenal damage, which is most likely attributed to their antioxidant and anti-inflammatory contents. Interestingly, when TM and CoQ were given in combination, a better restoration of Cd-induced liver and kidney damage was noticed than was during their individual treatments.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2022.954030