Recent Advances in Nanoparticle-Mediated Diagnosis and the Treatment of Pancreatic Cancer

Pancreatic cancer (PC), one of the most lethal solid tumors in humans, has a five-year survival rate of only 4%. Surgical treatment is the only accepted therapy with curative intent because the vast majority of these tumors are chemoresistant. Unfortunately, due to the aggressive nature of these tum...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-08, Vol.22 (15), p.8060
Main Authors: Nedelcu, Andreea, Mocan, Teodora, Grapa, Cristiana, Mocan, Lucian
Format: Article
Language:English
Subjects:
Biocompatibility
Cancer therapies
Chemotherapy
Cytotoxicity
Disease prevention
drug delivery
Hyaluronic acid
Magnetic resonance imaging
Nanoparticles
Nanotechnology
Pancreatic cancer
Review
Solid tumors
Transmission electron microscopy
Tumors
Ultrasonic imaging
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Summary:Pancreatic cancer (PC), one of the most lethal solid tumors in humans, has a five-year survival rate of only 4%. Surgical treatment is the only accepted therapy with curative intent because the vast majority of these tumors are chemoresistant. Unfortunately, due to the aggressive nature of these tumors, fewer than 20% are resectable when the first symptoms occur. Novel therapies are required to overcome all these therapeutic issues, and the development of active nanocarriers represents an exciting opportunity to improve PC outcomes. The present review focuses on recent advances in the field of nanotechnology with application in PC treatment.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22158060