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Meglumine-Promoted Eco-Compatible Pseudo-Three-Component Reaction for the Synthesis of 1,1-Dihomoarylmethane Scaffolds and Their Green Credentials

A simple, straightforward, and energy-efficient greener route for the synthesis of a series of biologically interesting functionalized 1,1-dihomoarylmethane scaffolds has been developed in the presence of meglumine as an efficient and eco-friendly organo-catalyst via one-pot pseudo-three-component r...

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Published in:ACS omega 2022-08, Vol.7 (34), p.30420-30439
Main Authors: Patel, Manan S., Parekh, Jaydeepkumar N., Chudasama, Dipakkumar D., Patel, Harsh C., Dalwadi, Priyanka, Kunjadiya, Anju, Bhatt, Vaibhav, Ram, Kesur R.
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cited_by cdi_FETCH-LOGICAL-a4271-b6514a87f68b81e9f2550b36a4ed3e2f6cb9bb2d5e78b3c8c54505e42c00a0253
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container_end_page 30439
container_issue 34
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container_title ACS omega
container_volume 7
creator Patel, Manan S.
Parekh, Jaydeepkumar N.
Chudasama, Dipakkumar D.
Patel, Harsh C.
Dalwadi, Priyanka
Kunjadiya, Anju
Bhatt, Vaibhav
Ram, Kesur R.
description A simple, straightforward, and energy-efficient greener route for the synthesis of a series of biologically interesting functionalized 1,1-dihomoarylmethane scaffolds has been developed in the presence of meglumine as an efficient and eco-friendly organo-catalyst via one-pot pseudo-three-component reaction at room temperature. Following this protocol, it is possible to synthesize 1,1-dihomoarylmethane scaffolds of an assortment of C–H activated acids such as dimedone, 1,3-cyclohexadione, 4-hydroxy-6-methyl-2-pyrone, 4-hydroxycoumarin, and 1-phenyl-3-methyl-pyrazolone. The salient features of the present green protocol are mild reaction conditions, good to excellent yields, operational simplicity, easy isolation of products, no cumbersome post treatment, high atom economy, and low E-factor. In addition, this chemistry portrays several green advantages including the reusability of reaction media and product scalability, which makes protocol sustainably efficient. Additionally, several control experiments such as protection of catalyst reactive site, D2O exchange, and 1H NMR studies revealed possible pathways for meglumine-promoted reactions. Inspired by the natural physiological environment of 1,1-dihomoarylmethane scaffolds, we reconnoitered the biological profile of our compounds and synthesized compounds that were promising for their antiproliferative and antibacterial activities.
doi_str_mv 10.1021/acsomega.2c03787
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title Meglumine-Promoted Eco-Compatible Pseudo-Three-Component Reaction for the Synthesis of 1,1-Dihomoarylmethane Scaffolds and Their Green Credentials
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