Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities

Norcantharidin (NCTD) is a demethylated derivative of cantharidin, which is an anticancer active ingredient of traditional Chinese medicine, and is currently used clinically as a routine anti-cancer drug in China. Clarifying the anticancer effect and molecular mechanism of NCTD is critical for its c...

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Bibliographic Details
Published in:Chinese medicine 2020-05, Vol.15 (1), p.55-55, Article 55
Main Authors: Pan, Mu-Su, Cao, Jin, Fan, Yue-Zu
Format: Article
Language:English
Subjects:
Anticancer activities
Antitumor agent
Apoptosis
Cancer therapies
Cell cycle
Cell division
Cell growth
Chinese medicine
Colorectal cancer
Cyclin-dependent kinases
Cytotoxicity
Deoxyribonucleic acid
DNA
Drug dosages
Esophageal cancer
Gallbladder
Gastric cancer
Kidneys
Kinases
Leukemia
Liver cancer
Lymphoma
Mechanism
NCTD
Norcantharidin
Ovarian cancer
Pharmacokinetics
Physiology
Proteins
Review
Signal transduction
Therapeutic applications
Traditional Chinese medicine
Tumors
Urogenital system
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Summary:Norcantharidin (NCTD) is a demethylated derivative of cantharidin, which is an anticancer active ingredient of traditional Chinese medicine, and is currently used clinically as a routine anti-cancer drug in China. Clarifying the anticancer effect and molecular mechanism of NCTD is critical for its clinical application. Here, we summarized the physiological, chemical, pharmacokinetic characteristics and clinical applications of NCTD. Besides, we mainly focus on its potential multi-target anticancer activities and underlying mechanisms, and discuss the problems existing in clinical application and scientific research of NCTD, so as to provide a potential anticancer therapeutic agent for human malignant tumors.
ISSN:1749-8546
1749-8546
DOI:10.1186/s13020-020-00338-6