Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility

The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not...

Full description

Saved in:
Bibliographic Details
Published in:Archives of biological sciences 2010, Vol.62 (3), p.525-530
Main Authors: Djordjevic, Valentina, Nikolic, A., Ljujic, M., Nestorovic, A., Ristanovic, M., Tulic, C., Radojkovic, D.
Format: Article
Language:English
Subjects:
ESTERILIDAD MASCULINA
GENE
gene mutation
GENERO HUMANO
GENES
GENRE HUMAIN
GSTM1
GSTT1
http://www.fao.org/aos/agrovoc#c_15995
http://www.fao.org/aos/agrovoc#c_3214
http://www.fao.org/aos/agrovoc#c_4537
http://www.fao.org/aos/agrovoc#c_4586
http://www.fao.org/aos/agrovoc#c_5014
INFERTILITE MALE
MACHO
MALE
MALE INFERTILITY
MALES
MANKIND
MTHFR
MUTACION
MUTATION
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analysed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30).
ISSN:0354-4664
1821-4339
DOI:10.2298/ABS1003525D