Study on expression of plasma sCD138 in patients with hemorrhagic fever with renal syndrome

• Published in: BMC infectious diseases 2018-03, Vol.18 (1), p.100-7, Article 100
• Main Authors: Li, Jing, Du, Hong, Bai, Xue-Fan, Wang, Xiao-Yan, Zhang, Ying, Jiang, Hong, Wang, Ping-Zhong
• Format: Article
• Language: English
• Subjects: Acute Disease; Adult; Alanine Transaminase - blood; Area Under Curve; Aspartate Aminotransferases - blood; Biological markers; Biomarkers - blood; Blood Urea Nitrogen; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Glycocalyx; Hantavirus; Hemorrhagic fever with renal syndrome; Hemorrhagic Fever with Renal Syndrome - blood; Hemorrhagic Fever with Renal Syndrome - pathology; Hemorrhagic Fever with Renal Syndrome - virology; Hemorrhagic fevers; Humans; Leukocyte Count; Male; Middle Aged; Orthohantavirus - isolation & purification; Prognosis; ROC Curve; Severity of Illness Index; Soluble CD138; Syndecan-1 - blood
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-018-3005-0

Until now, there is non-specific treatment, and exploring early and novel biomarkers to determine the disease severity and prognosis of hemorrhagic fever with renal syndrome (HFRS) would be of importance for clinician to take systematic and timely intervention. This study observed the expression of plasma sCD138, a soluble component shedding from the glycocalyx (GCX) to the circulating blood, and evaluated its predictive value on disease severity and prognosis of HFRS. One hundred and seventy-six patients with HFRS who were treated at our center between January 2011 and December 2013 were randomly enrolled in this study. The patients were divided into a mild-type group, a moderate-type group, a severe-type group and a critical-type group according to the HFRS criteria for clinical classification. Thirty-five blood samples from healthy subjects were obtained as the controls. The concentrations of sCD138 were detected using enzyme linked immunosorbent assay (ELISA). The levels of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fib), albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), white blood cells (WBC), platelets (PLT), glucose (GLU), blood urea nitrogen (BUN) and serum creatinine (Scr) in the samples were routinely tested. The levels of sCD138 among the different types were compared; the correlation among sCD138 and the laboratory parameters mentioned above were analyzed. The predictive effectiveness for prognosis of sCD138 was evaluated using the receiver operating characteristic (ROC) curve analysis. Except for the mild-type, the levels of sCD138 in the moderate-, severe- and critical-type patients during the acute stage were significantly higher than that of the convalescent stage and the control (P0.05). sCD138 was negatively correlated with Fib, PLT and ALB, and was positively correlated with WBC and AST (P