Mucus: An Underestimated Gut Target for Environmental Pollutants and Food Additives

Synthetic chemicals (environmental pollutants, food additives) are widely used for many industrial purposes and consumer-related applications, which implies, through manufactured products, diet, and environment, a repeated exposure of the general population with growing concern regarding health diso...

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Bibliographic Details
Published in:Microorganisms (Basel) 2018-06, Vol.6 (2), p.53
Main Authors: Gillois, Kévin, Lévêque, Mathilde, Théodorou, Vassilia, Robert, Hervé, Mercier-Bonin, Muriel
Format: Article
Language:English
Subjects:
Additives
Autoimmune diseases
Bacteria
Binding sites
Chemicals
Crosstalk
Digestive system
Disease
Ecological risk assessment
Emulsifiers
Environmental management
environmental pollutants
Food additives
Gastrointestinal system
Gastrointestinal tract
Gene expression
gut barrier
Heavy metals
Homeostasis
Intestinal microflora
Intestine
Life Sciences
Metabolism
Microbiota
Microorganisms
mucophilic bacteria
Mucus
Nanomaterials
Nanoparticles
Nanotechnology
Organic chemistry
Oxidative stress
Permeability
Persistent organic pollutants
Pesticides
Pollutants
Proteins
Review
Risk assessment
Rodents
Toxicity
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Summary:Synthetic chemicals (environmental pollutants, food additives) are widely used for many industrial purposes and consumer-related applications, which implies, through manufactured products, diet, and environment, a repeated exposure of the general population with growing concern regarding health disorders. The gastrointestinal tract is the first physical and biological barrier against these compounds, and thus their first target. Mounting evidence indicates that the gut microbiota represents a major player in the toxicity of environmental pollutants and food additives; however, little is known on the toxicological relevance of the mucus/pollutant interplay, even though mucus is increasingly recognized as essential in gut homeostasis. Here, we aimed at describing how environmental pollutants (heavy metals, pesticides, and other persistent organic pollutants) and food additives (emulsifiers, nanomaterials) might interact with mucus and mucus-related microbial species; that is, “mucophilic” bacteria such as mucus degraders. This review highlights that intestinal mucus, either directly or through its crosstalk with the gut microbiota, is a key, yet underestimated gut player that must be considered for better risk assessment and management of environmental pollution.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms6020053