Immunohistochemical Expression of Cyclo-oxygenase 2 and Liver X Receptor-α in Acne Vulgaris

• Published in: Journal of clinical and diagnostic research 2017-09, Vol.11 (9), p.WC01-WC07
• Main Authors: Bakry, Ola Ahmed, El Farargy, Shawky Mahmoud, El Kady, Noha Nour El Din, Dawy, Hend Farag Abu
• Format: Article
• Language: English
• Subjects: Dermatology Section; immunohistochemistry; inflammation; lipogenesis; pilosebaceous unit
• ISSN: 2249-782X; 0973-709X
• DOI: 10.7860/JCDR/2017/28754.10577

Acne Vulgaris (AV) is a common inflammatory disease of pilosebaceous units. Liver X Receptor-α (LXR-α) is a ligand activated transcription factor. It controls transcription of genes involved in lipid and fatty acid synthesis. Cyclo-oxygenase 2 (COX2) is a rate limiting enzyme in prostaglandin synthesis. It plays important role in inflammation. To evaluate the immunohistochemical expression of LXR-α and COX2 in acne vulgaris skin biopsies to explore their possible pathogenic role in this disease. Sixty five subjects were included (45 cases with AV and 20 age and gender-matched healthy controls). Skin biopsies were taken from lesional and perilesional skin of cases and from site-matched areas of control subjects. The evaluation of LXR-α and COX2 was done using immunohistochemical technique. Data were collected, tabulated and statistically analysed using a personal computer with "(SPSS) version 11" program. Chi-square test was used to study the association between qualitative variables. Mann-Whitney test was used for comparison between quantitative variables. Student's t-test was used for comparison between two groups having quantitative variables. Spearman's coefficient was used to study the correlation between two different variables. Differences were considered statistically significant with p