Monoclonal Gammopathy of Renal Significance with Progression to Multiple Myeloma in a Patient with ASIA-MO Syndrome

Background. Autoimmune/inflammatory syndrome induced by adjuvants is a disease associated with an unregulated hyperactivity of the immune system and may also be associated with a high frequency of hematologic malignancies. Report. This is a case of a female with ASIA-MO syndrome secondary to infiltr...

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Published in:Case reports in hematology 2022-05, Vol.2022, p.8571536-8
Main Authors: Vargas Gutiérrez, David Alejandro, Arias Callejas, Karina Ivonne, Palacios Ruiz, Edwin Pavel, Pérez Vinueza, Priscila Joseline, Muñoz Vega, Juan Diego, Mejía Geraldo, Ana Karen G., Zaldívar, Ingrid Salinas
Format: Article
Language:English
Subjects:
Amyloidosis
Anemia
Asymptomatic
Biopsy
Blood
Case Report
Case reports
Cell cycle
Cytokines
Development and progression
Hemoglobin
Hydrochlorothiazide
Hypercalcemia
Immunoglobulins
Kidney diseases
Light
Multiple myeloma
Patients
Petroleum products
Plasma
Proteins
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Summary:Background. Autoimmune/inflammatory syndrome induced by adjuvants is a disease associated with an unregulated hyperactivity of the immune system and may also be associated with a high frequency of hematologic malignancies. Report. This is a case of a female with ASIA-MO syndrome secondary to infiltration of mineral oil for aesthetic purposes and presented with multiple episodes of urolithiasis resulting in renal impairment of her left kidney confirmed by scintigraphy and ending in unilateral nephrectomy. Retrospective renal piece analysis confirmed tubulointerstitial infiltration with light chains and plasma cells. Paraffin fixation prevented subsequent immunofluorescence analysis for better follow-up of the patient. Conclusion. The presence of positive immunofixation kappa chains explained the sudden deterioration of renal function with monoclonal gammopathy of renal significance which concluded in an association between diseases, such as multiple light chain myeloma, as a final diagnosis.
ISSN:2090-6560
2090-6579
DOI:10.1155/2022/8571536