Protective Effect of Cudrania tricuspidata Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway

Nonalcoholic fatty liver disease is the most common chronic disease affecting a wide range of the world's population and associated with obesity-induced metabolic syndrome. It is possibly emerging as a leading cause of life-threatening liver diseases for which a drug with a specific therapeutic...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-04, Vol.26 (9), p.2434
Main Authors: Shrestha, Jitendra, Baek, Dong-Jae, Oh, Yoon-Sin, Cho, Sam-Seok, Ki, Sung-Hwan, Park, Eun-Young
Format: Article
Language:English
Subjects:
antioxidant
Body fat
Body weight
Cholesterol
Cudrania tricuspidata
Cytokines
Diabetes mellitus
erythroid 2 like 2
Fatty acids
Fatty liver
Food
GA-binding protein
Gene expression
Genes
Glucose
High fat diet
Inflammation
Insulin resistance
Lipid peroxidation
Lipids
Lipogenesis
Lipolysis
Liver
Liver diseases
Metabolic disorders
Metabolic syndrome
Metabolism
nonalcoholic fatty liver disease
nuclear factor
Obesity
Oral administration
Oxidation
Oxidative stress
Penicillin
Proteins
Steatosis
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Summary:Nonalcoholic fatty liver disease is the most common chronic disease affecting a wide range of the world's population and associated with obesity-induced metabolic syndrome. It is possibly emerging as a leading cause of life-threatening liver diseases for which a drug with a specific therapeutic target has not been developed yet. Previously, there have been reports on the benefits of (CT) for treating obesity and diabetes via regulation of metabolic processes, such as lipogenesis, lipolysis, and inflammation. In this study, we investigated the ameliorative effect of orally administered 0.25% and 0.5% ( / ) CT mixed with high-fat diet (HFD) to C57BL/6J mice for 7 weeks. It was found that body weight, fat mass, hepatic mass, serum glucose level, and liver cholesterol levels were significantly reduced after CT treatment. In CT-treated HFD-fed mice, the mRNA expression levels of hepatic lipogenic and inflammatory cytokine-related genes were markedly reduced, whereas the expression level of epididymal lipogenic genes was increased. The mRNA expression level of beta-oxidation and Nrf-2/HO-1 genes significantly increased in CT-treated obese mice livers. We propose that CT alleviates hepatic steatosis by reducing oxidative stress and inflammation.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26092434