Pilot Study on Visual Function and Fundus Autofluorescence Assessment in Diabetic Patients

Purpose. Evaluate optimized fundus autofluorescence (FAF) imaging in early stages of diabetic retinopathy (DR) and relate findings with conventional colour fundus imaging and visual function in diabetic patients and control subjects. Materials and Methods. FAF and colour images were obtained using t...

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Bibliographic Details
Published in:Journal of Ophthalmology 2016-01, Vol.2016 (2016), p.62-71-008
Main Authors: Calvo-Maroto, Ana M, Esteve-Taboada, Jose J, Perez-Cambrodi, Rafael J, Madrid-Costa, David, Cervino, Alejandro
Format: Article
Language:English
Subjects:
Activities of daily living
Age
Body mass index
Care and treatment
Development and progression
Diabetes
Diabetic retinopathy
Diagnosis
Edema
Fasting
Fluorescence microscopy
Glucose
Macular degeneration
Patients
Quality of life
Risk factors
Statistical analysis
Studies
Visual impairment
Womens health
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Summary:Purpose. Evaluate optimized fundus autofluorescence (FAF) imaging in early stages of diabetic retinopathy (DR) and relate findings with conventional colour fundus imaging and visual function in diabetic patients and control subjects. Materials and Methods. FAF and colour images were obtained using the CR-2 Plus digital nonmydriatic retinal camera in seven diabetic patients and thirteen control subjects. Visual-Functioning Questionnaire-25 (VFQ-25) and Diabetes Self-Management Questionnaire (DSMQ) were used to assess the quality of life and diabetes self-care. Contrast sensitivity function (CSF) was evaluated with the Vistech 6500 chart. Results. FAF and optimized-FAF imaging showed more retinal alterations related to DR than colour imaging. In diabetic patients, compatible signs with microaneurysms, capillary dilations, and haemorrhages were less numerous in colour imaging than optimized-FAF and FAF imaging in areas analysed. Control subjects at risk of developing DM showed more retinal pigment epithelium defects than those without risk in all retinal areas. Significant differences were not found in VFQ-25 and CSF between diabetic patients and control subjects. Conclusions. FAF and optimized-FAF imaging showed significant alterations related to DR not observed in colour imaging. FAF and optimized-FAF images could be a useful complementary tool for detecting early alterations associated with the development and progression of DR.
ISSN:2090-004X
2090-0058
DOI:10.1155/2016/1287847