Gastroprotective Effects of Inulae Flos on HCl/Ethanol-Induced Gastric Ulcers in Rats

• Published in: Molecules (Basel, Switzerland) Switzerland), 2020-11, Vol.25 (23), p.5623
• Main Authors: Kim, Young-Sik, Lee, Ji Hyeon, Song, Jungbin, Kim, Hocheol
• Format: Article
• Language: English
• Subjects: Animals; antioxidant; Antioxidants; Antioxidants - metabolism; Catalase; Catalase - metabolism; Dinoprostone - metabolism; Disease Models, Animal; Enzymatic activity; Enzyme activity; Enzymes; Ethanol; Ethanol - toxicity; Flavonoids; Flowers - chemistry; Gastric Juice - drug effects; Gastric Mucosa - drug effects; Gastric Mucosa - pathology; gastric ulcer; gastric wall mucus; Gastritis; Glutathione Peroxidase - metabolism; Hydrochloric acid; Hydrochloric Acid - toxicity; Hydrogen peroxide; Inula - chemistry; Inula britannica; Lesions; Male; Malondialdehyde - metabolism; Mucosa; Mucus; Mucus - metabolism; Oxidative stress; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Pretreatment; Prostaglandin E2; Protective Agents - administration & dosage; Protective Agents - pharmacology; Rats, Sprague-Dawley; Secretion; Stomach; Stomach Ulcer - chemically induced; Stomach Ulcer - drug therapy; Stomach Ulcer - pathology; Superoxide dismutase; Superoxide Dismutase - metabolism; Ulcers
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25235623

Inulae Flos, the flower of L., is used as a dietary supplement, beverage, and medicine in East Asia. In this study, we evaluated the gastroprotective effects of Inulae Flos extract (IFE) against gastric mucosal lesions induced by hydrochloric acid (HCl)/ethanol in rats and explored its potential mechanisms by measuring antioxidant enzyme activity, mucus secretion, and prostaglandin E (PGE ) levels. Pretreatment with IFE at doses of 100 and 300 mg/kg significantly inhibited gastric lesions in HCl/ethanol-treated rats. IFE increased the activities of superoxide dismutase and catalase and the levels of glutathione and PGE in gastric tissues. The administration of IFE also significantly increased the gastric wall mucus contents in HCl/ethanol-induced gastric lesions. These findings suggest that IFE has gastroprotective effects against HCl/ethanol-induced gastric lesions and exerts these effects through increased antioxidant levels and gastric mucus secretion. Inulae Flos may be a promising agent for the prevention and treatment of gastritis and gastric ulcers.