Resonant laser ionization and mass separation of 225Ac

225 Ac is a radio-isotope that can be linked to biological vector molecules to treat certain distributed cancers using targeted alpha therapy. However, developing 225 Ac-labelled radiopharmaceuticals remains a challenge due to the supply shortage of pure 225 Ac itself. Several techniques to obtain p...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2023-01, Vol.13 (1), p.1347-1347, Article 1347
Main Authors: Johnson, Jake D., Heines, Michael, Bruchertseifer, Frank, Chevallay, Eric, Cocolios, Thomas E., Dockx, Kristof, Duchemin, Charlotte, Heinitz, Stephan, Heinke, Reinhard, Hurier, Sophie, Lambert, Laura, Leenders, Benji, Skliarova, Hanna, Stora, Thierry, Wojtaczka, Wiktoria
Format: Article
Language:English
Subjects:
639/766/387/1126
692/4028/67/1059/602
Cancer therapies
Generators
Humanities and Social Sciences
Ion beams
Ionization
Lasers
Mass spectrometry
Mass spectroscopy
multidisciplinary
Radiation
Rhenium
Science
Science (multidisciplinary)
Scientific imaging
Thorium
Tumors
Uranium
Vectors (Biology)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:225 Ac is a radio-isotope that can be linked to biological vector molecules to treat certain distributed cancers using targeted alpha therapy. However, developing 225 Ac-labelled radiopharmaceuticals remains a challenge due to the supply shortage of pure 225 Ac itself. Several techniques to obtain pure 225 Ac are being investigated, amongst which is the high-energy proton spallation of thorium or uranium combined with resonant laser ionization and mass separation. As a proof-of-principle, we perform off-line resonant ionization mass spectrometry on two samples of 225 Ac, each with a known activity, in different chemical environments. We report overall operational collection efficiencies of 10.1(2)% and 9.9(8)% for the cases in which the 225 Ac was deposited on a rhenium surface and a ThO 2 mimic target matrix respectively. The bottleneck of the technique was the laser ionization efficiency, which was deduced to be 15.1(6)%.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-28299-4