Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

• Published in: Nature communications 2020-10, Vol.11 (1), p.5009-5009, Article 5009
• Main Authors: Burn, Edward, You, Seng Chan, Sena, Anthony G., Kostka, Kristin, Abedtash, Hamed, Abrahão, Maria Tereza F., Alberga, Amanda, Alghoul, Heba, Alser, Osaid, Alshammari, Thamir M., Aragon, Maria, Areia, Carlos, Banda, Juan M., Cho, Jaehyeong, Culhane, Aedin C., Davydov, Alexander, DeFalco, Frank J., Duarte-Salles, Talita, DuVall, Scott, Falconer, Thomas, Fernandez-Bertolin, Sergio, Gao, Weihua, Golozar, Asieh, Hardin, Jill, Hripcsak, George, Huser, Vojtech, Jeon, Hokyun, Jing, Yonghua, Jung, Chi Young, Kaas-Hansen, Benjamin Skov, Kaduk, Denys, Kent, Seamus, Kim, Yeesuk, Kolovos, Spyros, Lane, Jennifer C. E., Lee, Hyejin, Lynch, Kristine E., Makadia, Rupa, Matheny, Michael E., Mehta, Paras P., Morales, Daniel R., Natarajan, Karthik, Nyberg, Fredrik, Ostropolets, Anna, Park, Rae Woong, Park, Jimyung, Posada, Jose D., Prats-Uribe, Albert, Rao, Gowtham, Reich, Christian, Rho, Yeunsook, Rijnbeek, Peter, Schilling, Lisa M., Schuemie, Martijn, Shah, Nigam H., Shoaibi, Azza, Song, Seokyoung, Spotnitz, Matthew, Suchard, Marc A., Swerdel, Joel N., Vizcaya, David, Volpe, Salvatore, Wen, Haini, Williams, Andrew E., Yimer, Belay B., Zhang, Lin, Zhuk, Oleg, Prieto-Alhambra, Daniel, Ryan, Patrick
• Format: Article
• Language: English
• Subjects: 631/326/596/2562; 631/326/596/4130; 692/308/174; 692/499; Adult; Age Factors; Aged; Aged, 80 and over; Cohort Studies; Comorbidity; Coronavirus Infections - drug therapy; Coronavirus Infections - epidemiology; COVID-19; Female; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi; Hospitalization; Humanities and Social Sciences; Humans; Infectious Medicine; Infektionsmedicin; Influenza, Human - drug therapy; Influenza, Human - epidemiology; Male; Middle Aged; multidisciplinary; Pandemics; Pneumonia, Viral - drug therapy; Pneumonia, Viral - epidemiology; Prevalence; Public Health, Global Health, Social Medicine and Epidemiology; Republic of Korea - epidemiology; Science; Science (multidisciplinary); Sex Factors; Spain - epidemiology; United States - epidemiology; Young Adult
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-020-18849-z

Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19. Detailed knowledge of the characteristics of COVID-19 patients helps with public health planning. Here, the authors use routinely-collected data from seven databases in three countries to describe the characteristics of >30,000 patients admitted with COVID-19 and compare them with those admitted for influenza in previous years.