Separation Methods of Phenolic Compounds from Plant Extract as Antioxidant Agents Candidate

In recent years, discovering new drug candidates has become a top priority in research. Natural products have proven to be a promising source for such discoveries as many researchers have successfully isolated bioactive compounds with various activities that show potential as drug candidates. Among...

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Bibliographic Details
Published in:Plants (Basel) 2024-04, Vol.13 (7), p.965
Main Authors: Susanti, Ike, Pratiwi, Rimadani, Rosandi, Yudi, Hasanah, Aliya Nur
Format: Article
Language:English
Subjects:
Acids
antioxidant
Antioxidants
Apoptosis
Bioactive compounds
Biological activity
Cancer
Chemical properties
Chromatography
Column chromatography
Cytokines
Diabetes
DNA damage
Drug development
Extraction (Chemistry)
Free radicals
Gene expression
Herbal medicine
High performance liquid chromatography
isolation
Liquid chromatography
Materia medica, Vegetable
Medical treatment
Medicine
Metabolites
Methods
Natural products
Oxidation
Oxidative stress
Pharmaceutical research
Pharmaceuticals
Phenolic compounds
Phenols
plant extract
Plant extracts
Separation
Solvents
Supercritical fluids
Thin layer chromatography
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Summary:In recent years, discovering new drug candidates has become a top priority in research. Natural products have proven to be a promising source for such discoveries as many researchers have successfully isolated bioactive compounds with various activities that show potential as drug candidates. Among these compounds, phenolic compounds have been frequently isolated due to their many biological activities, including their role as antioxidants, making them candidates for treating diseases related to oxidative stress. The isolation method is essential, and researchers have sought to find effective procedures that maximize the purity and yield of bioactive compounds. This review aims to provide information on the isolation or separation methods for phenolic compounds with antioxidant activities using column chromatography, medium-pressure liquid chromatography, high-performance liquid chromatography, counter-current chromatography, hydrophilic interaction chromatography, supercritical fluid chromatography, molecularly imprinted technologies, and high-performance thin layer chromatography. For isolation or purification, the molecularly imprinted technologies represent a more accessible and more efficient procedure because they can be applied directly to the extract to reduce the complicated isolation process. However, it still requires further development and refinement.
ISSN:2223-7747
2223-7747
DOI:10.3390/plants13070965