Association of urinary prostaglandin E2 metabolite and mortality among adults

Prostaglandins play a critical role in inflammatory response. To investigate the association of urinary PGE-M, a stable end-product of prostaglandin E2 (PGE 2 ) with overall and cause-specific mortality and examine potential effect modifiers, we obtained urinary PGE-M levels of 2927 non-cancerous ad...

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Bibliographic Details
Published in:Scientific reports 2022-11, Vol.12 (1), p.18905-18905, Article 18905
Main Authors: Wen, Wanqing, Yang, Gong, Cai, Qiuyin, Shu, Xiao-Ou, Zheng, Wei
Format: Article
Language:English
Subjects:
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Adult
Cardiovascular Diseases
Case-Control Studies
China - epidemiology
Cohort analysis
Cohort Studies
Confidence intervals
Dinoprostone
Education
Female
Health hazards
Humanities and Social Sciences
Humans
Inflammation
Male
Metabolites
Mortality
multidisciplinary
Prostaglandin E2
Prostaglandins
Prostaglandins E
Regression analysis
Risk Factors
Science
Science (multidisciplinary)
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Summary:Prostaglandins play a critical role in inflammatory response. To investigate the association of urinary PGE-M, a stable end-product of prostaglandin E2 (PGE 2 ) with overall and cause-specific mortality and examine potential effect modifiers, we obtained urinary PGE-M levels of 2927 non-cancerous adults from our previous case-control studies nested in the Shanghai Women’s Health Study and Shanghai Men’s Health Study, two cohort studies conducted in Shanghai, China. Mortality data and modifiable factors associated with urinary PGE-M were obtained from the parent cohort studies. Using linear regression models, we found that high urinary PGE-M levels were significantly associated with low education, heaving smoking, old age at urine collection, and abdominal obesity. Using Cox proportional hazards models, we found that increase (per standard deviation) of urinary PGE-M levels were significantly associated with overall mortality (adjusted hazard ratio = 1.19, 95% confidence interval: 1.07, 1.33) and particularly deaths from cardiometabolic diseases (adjusted hazard ratio = 1.27, 95% confidence interval: 1.11, 1.44). The increased death risks persisted across different time intervals during the follow-up and were stronger among participants who were younger than 60 ( P  = 0.0014 for all- cause mortality and P  = 0.007 for deaths from cardiometabolic diseases) at urine collection or perhaps among those who had higher education.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-23773-x