Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures

Although many common variants have been identified for bone mineral density (BMD) and osteoporosis fractures, all the identified risk variants could only explain a small portion of heritability of BMD and osteoporosis fractures. OPG belongs to the tumor necrosis factor receptor superfamily, which pl...

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Bibliographic Details
Published in:Scientific reports 2017-05, Vol.7 (1), p.1739-7, Article 1739
Main Authors: Sheng, Xiaoyong, Cai, Guangyong, Gong, Xingjun, Yao, Zouying, Zhu, Ye
Format: Article
Language:English
Subjects:
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Bone density
Bone Density - genetics
Bone mineral density
Bone remodeling
Data processing
Demography
Female
Fractures
Genetic Predisposition to Disease
Heritability
Humanities and Social Sciences
Humans
multidisciplinary
Osteoporosis
Osteoporotic Fractures - genetics
Osteoporotic Fractures - physiopathology
Osteoprotegerin
Osteoprotegerin - genetics
Polymorphism, Single Nucleotide - genetics
Population studies
Post-menopause
Postmenopause - genetics
Risk Factors
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
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Summary:Although many common variants have been identified for bone mineral density (BMD) and osteoporosis fractures, all the identified risk variants could only explain a small portion of heritability of BMD and osteoporosis fractures. OPG belongs to the tumor necrosis factor receptor superfamily, which plays a crucial role in bone remodeling and is thus a promising candidate gene of osteoporosis. Several studies have explored the association of OPG variants with BMD or osteoporosis fractures, however, the results remain inconsistent among different populations. In the study, we first assessed the relationship between OPG variants and BMD or osteoporosis fractures in our sample size (227 subjects with postmenopausal osteoporosis and 189 controls), and then performed a systematic meta-analysis. Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-01579-6