Pregnancy rest-activity patterns are related to salivary cortisol rhythms and maternal-fetal health indicators in women from a disadvantaged population

Irregular rest-activity patterns can disrupt metabolic and hormonal physiology and potentially lead to disease. Little is known regarding rest-activity patterns during gestation and their association with hormonal rhythms and health in pregnant women. We conducted a pilot study to determine if 24 h...

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Bibliographic Details
Published in:PloS one 2020-03, Vol.15 (3), p.e0229567-e0229567
Main Authors: Casey, Theresa, Sun, Hui, Suarez-Trujillo, Aridany, Crodian, Jennifer, Zhang, Lingsong, Plaut, Karen, Burgess, Helen J, Dowden, Shelley, Haas, David M, Ahmed, Azza
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Blood glucose
Diseases
Enzyme-linked immunosorbent assay
Glucocorticoids
Glucose
Health aspects
Medicine and Health Sciences
Physiological aspects
Pregnancy
Pregnant women
Sleep
Time
Women's health
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Summary:Irregular rest-activity patterns can disrupt metabolic and hormonal physiology and potentially lead to disease. Little is known regarding rest-activity patterns during gestation and their association with hormonal rhythms and health in pregnant women. We conducted a pilot study to determine if 24 h rest-activity was related to saliva cortisol rhythms and maternal-fetal health in an economically disadvantaged population. Primiparous women wore a wrist actigraphy device for a week to record activity during gestational weeks 22 (G22; n = 50) and 32 (G32; n = 46) and postpartum week one (PPW1; n = 39). Participants collected saliva samples every 4 hr over a 24 hr period during G22 (n = 22), G32 (n = 20) and 24-48 hr postnatal (n = 20), and cortisol concentrations were measured with ELISA. Circadian rhythmicity was assessed using autocorrelation coefficient (r24) and cosinor analysis. Blood glucose levels, body mass index (BMI), gestational disease data, and gestational age of infant at birth were abstracted from medical charts. Time of cortisol peak (acrophase) during G22 was related with acrophase of activity (r = 0.66; p = 0.001) and blood glucose levels (r = 0.58; p = 0.006). During G22, minutes of wake after sleep onset was positively related to cortisol mesor and AUC (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0229567