Correlation between Morphological Characteristics of Macular Edema and Visual Acuity in Young Patients with Idiopathic Intermediate Uveitis

Macular edema (ME) is a common complication of intermediate uveitis (IU). It is often responsible for a decrease in visual acuity (VA). Three distinct patterns of macular edema have been described in intermediate uveitis, namely, cystoid macular edema (CME), diffuse macular edema (DME), and serous r...

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Published in:Medicina (Kaunas, Lithuania) Lithuania), 2023-03, Vol.59 (3), p.529
Main Authors: Iannetti, Ludovico, Scarinci, Fabio, Alisi, Ludovico, Armentano, Marta, Sampalmieri, Lorenzo, La Cava, Maurizio, Gharbiya, Magda
Format: Article
Language:English
Subjects:
Edema
Epstein-Barr virus
Humans
Infectious diseases
Inflammation
intermediate uveitis
macular edema
Macular Edema - etiology
Morphology
Multiple sclerosis
optical coherence tomography
Patients
Phlebitis
Photoreceptors
Retinal detachment
Retinal Detachment - complications
retinal morphology
Retrospective Studies
Sarcoidosis
Steroids
Tomography, Optical Coherence - methods
Uveitis, Intermediate - complications
Visual Acuity
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Summary:Macular edema (ME) is a common complication of intermediate uveitis (IU). It is often responsible for a decrease in visual acuity (VA). Three distinct patterns of macular edema have been described in intermediate uveitis, namely, cystoid macular edema (CME), diffuse macular edema (DME), and serous retinal detachment (SRD). The current study aims to describe the characteristics of macular edema in young patients with idiopathic intermediate uveitis and to correlate its features with VA using spectral domain optical coherence tomography (SD-OCT). A total of 27 eyes from 18 patients with idiopathic IU complicated by ME were included in this retrospective study. All patients underwent SD-OCT; data were gathered at the onset of ME. Best-corrected VA (BCVA) was correlated with the morphological features of ME. BCVA was negatively correlated with Ellipsoid Zone (EZ) disruption ( = 0.00021), cystoid pattern ( = 0.00021), central subfield thickness (CST) ( < 0.001), and serous retinal detachment (0.037). In ME secondary to idiopathic IU, VA negatively correlates with Ellipsoid Zone disruption and increases in CST. Moreover, vision is influenced by the presence of cysts in the inner nuclear and outer nuclear layers and by the neuroepithelium detachment.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina59030529