Allergic diseases attributable to atopy in a population sample of Asian children

The proportion of allergic diseases attributable to atopy remains a subject of controversy. This study aimed to estimate the population risk of physician-diagnosed asthma, rhinitis and eczema attributed to atopy among a population sample of Asian school-age children. Asian children aged 5–18 years (...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2021-08, Vol.11 (1), p.1-8, Article 16052
Main Authors: Wu, Chao-Yi, Huang, Hsin-Yi, Pan, Wen-Chi, Liao, Sui-Ling, Hua, Man-Chin, Tsai, Ming-Han, Lai, Shen-Hao, Yeh, Kuo-Wei, Chen, Li-Chen, Huang, Jing-Long, Yao, Tsung-Chieh
Format: Article
Language:English
Subjects:
631/250
692/53
692/699
Allergens
Allergic diseases
Allergies
Asthma
Atopy
Children
Eczema
Humanities and Social Sciences
Immunoglobulin E
Immunoglobulins
International studies
multidisciplinary
Population
Population studies
Rhinitis
Science
Science (multidisciplinary)
Skin diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The proportion of allergic diseases attributable to atopy remains a subject of controversy. This study aimed to estimate the population risk of physician-diagnosed asthma, rhinitis and eczema attributed to atopy among a population sample of Asian school-age children. Asian children aged 5–18 years (n = 1321) in the Prediction of Allergies in Taiwanese CHildren (PATCH) study were tested for serum allergen-specific immunoglobulin E. Physician-diagnosed asthma, rhinitis and eczema were assessed by a modified International Study of Asthma and Allergies in Childhood questionnaire. Atopy was defined as the presence of serum allergen-specific immunoglobulin E. In this population-based study, 50.4% of the subjects with asthma, 46.3% with rhinitis, and 46.7% with eczema were attributable to atopy. The population attributable risk (PAR) of atopy for three allergic diseases was higher in adolescents (asthma, 54.4%; rhinitis, 59.6%; eczema, 49.5%) than younger children aged less than 10 years (asthma, 46.9%; rhinitis, 39.5%; eczema, 41.9%). Among the seven allergen categories, sensitization to mites had the highest PARs for all three allergic diseases (51.3 to 64.1%), followed by sensitization to foods (asthma, 7.1%; rhinitis, 10.4%; eczema 27.7%). In conclusion, approximately half (46.3 to 50.4%) of Asian children in Taiwan with allergic diseases are attributable to atopy.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-95579-2