Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults

Transcription of the cathelicidin antimicrobial peptide (CAMP) gene is induced by binding of the bioactive form of vitamin D, 1,25-dihydroxyvitamin D, to the vitamin D receptor. Significant levels of the protein hCAP18/LL-37 are found in the blood and may protect against infection and/or sepsis. We...

Full description

Saved in:
Bibliographic Details
Published in:BMC research notes 2012-10, Vol.5 (1), p.575-575, Article 575
Main Authors: Dixon, Brian M, Barker, Tyler, McKinnon, Toni, Cuomo, John, Frei, Balz, Borregaard, Niels, Gombart, Adrian F
Format: Article
Language:English
Subjects:
25-hydroxyvitamin D
Adult
Age
Alfacalcidol
Analysis
Antimicrobial agents
Antimicrobial Cationic Peptides
Bacterial infections
Calcifediol
CAMP
Cathelicidin
Cathelicidins
Cathelicidins - blood
Female
Gene expression
hCAP18
Health aspects
Health sciences
Hospitals
Humans
Immunity
Infection
Infections
LL-37
Male
Measurement
Middle Aged
Older people
Peptides
Plasma
Reference Values
Sepsis
Serum
Short Report
Studies
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Transcription of the cathelicidin antimicrobial peptide (CAMP) gene is induced by binding of the bioactive form of vitamin D, 1,25-dihydroxyvitamin D, to the vitamin D receptor. Significant levels of the protein hCAP18/LL-37 are found in the blood and may protect against infection and/or sepsis. We hypothesized that serum vitamin D levels may modulate the circulating levels of hCAP18. Only three studies have shown a positive correlation between circulating 25-hydroxyvitamin D and hCAP18 levels. Here we provide additional evidence for such a correlation in healthy, middle-aged adults. Serum levels of 25-hydroxyvitamin D [25(OH)D] and plasma levels of hCAP18 were determined in 19 healthy middle-aged (mean of 50.1 years) adult men and women. Plasma hCAP18 concentrations correlated with serum 25(OH)D concentrations in subjects with 25(OH)D levels ≤ 32 ng/ml (r = 0.81, p < 0.005) but not in subjects with concentrations > 32 ng/ml (r = 0.19, p = 0.63). We conclude that plasma hCAP18 levels correlate with serum 25(OH)D levels in subjects with concentrations of 25(OH)D ≤ 32 ng/ml as opposed to those with concentrations > 32 ng/ml and that vitamin D status may regulate systemic levels of hCAP18/LL-37.
ISSN:1756-0500
1756-0500
DOI:10.1186/1756-0500-5-575