The effect of prostate tissue inflammation in benign prostatic hyperplasia on enhancer of zeste homolog 2 ribonucleic acid expression

Enhancer of zeste homolog 2 (EZH2) has been recently found to regulate several genes involved in immunoresponse and autocrine inflammation network. The aim of the study was to quantitate EZH2 messenger ribonucleic acid (mRNA) expression, evaluate its relation to conditions of prostatitis associated...

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Bibliographic Details
Published in:Annals of Saudi medicine 2012-05, Vol.32 (3), p.262-268
Main Authors: Al-Maghrebi, May, Kehinde, Elijah O, Al-Mulla, Fahd, Anim, Jehoram T
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigens
Biomarkers
Biopsy
Cross-Sectional Studies
Deoxyribonucleic acid
DNA
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Enhancer of Zeste Homolog 2 Protein
Gene expression
Genital diseases
Histology
Humans
Hyperplasia
Inflammation
Interleukin-6 - blood
Male
Middle Aged
Original
Pathogenesis
Patients
Polycomb Repressive Complex 2
Polymerase chain reaction
Prostate - pathology
Prostate cancer
Prostate-Specific Antigen - blood
Prostatic Hyperplasia - complications
Prostatic Hyperplasia - metabolism
Prostatic Hyperplasia - pathology
Prostatitis - complications
Prostatitis - metabolism
Prostatitis - pathology
RNA, Messenger - analysis
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:Enhancer of zeste homolog 2 (EZH2) has been recently found to regulate several genes involved in immunoresponse and autocrine inflammation network. The aim of the study was to quantitate EZH2 messenger ribonucleic acid (mRNA) expression, evaluate its relation to conditions of prostatitis associated with benign prostatic hyperplasia (BPH), and correlate it with the levels of the inflammatory marker interlukin 6 (IL-6). Cross-sectional study in Middle Eastern men with BPH and prostatitis or BPH only. Transrectal ultrasound-guided prostate biopsies were collected from 106 patients suspected of having prostate cancer; however, the histology revealed BPH. Upon further pathological examination, 56 of these cases were identified as BPH with prostatitis and classified as: acute prostatitis (n=13); active chronic prostatitis (n=32); and, chronic inactive prostatitis (n=12). Serum IL-6 levels and EZH2 mRNA expression were measured and compared between patient groups. EZH2 mRNA was overexpressed in BPH with prostatitis patients compared to BPH only patients (P
ISSN:0256-4947
0975-4466
DOI:10.5144/0256-4947.2012.262