Preparation and Effect of Selenium Nanoparticles/Oligochitosan on the White Blood Cell Recovery of Mice Exposed to Gamma-Ray Radiation

Owing to their excellent bioavailability, high bioactivity, and low toxicity, selenium nanoparticles (SeNPs) are emerging nanomaterials. In this study, SeNPs with a size of ∼41.8 nm were synthesised by γ-irradiation using oligochitosan (OCS) as the stabiliser. As-synthesized SeNPs/OCS were character...

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Bibliographic Details
Published in:Journal of chemistry 2021-02, Vol.2021, p.1-9
Main Authors: Nguyen, Duy Ngoc, Van Dang, Phu, Le, Quoc Anh, Kim Nguyen, Lan Thi, Nguyen, Hien Quoc, Thu Tran, Ngan Thi, Le Bao Tran, Ha, Phan, Tuan Dinh, Bui, Ha Manh
Format: Article
Language:English
Subjects:
Ambient temperature
Backup software
Bioavailability
Biocompatibility
Blood
Blood cell count
Cancer therapies
Chemotherapy
Dosimetry
Gamma irradiation
Gamma rays
Immune system
Laboratory animals
Leukocytes
Molecular weight
Nanomaterials
Nanoparticles
Particle size
Purity
R&D
Radiation therapy
Radiotherapy
Research & development
Selenium
Spectrum analysis
Stability tests
Stabilizers (agents)
Toxicity
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Summary:Owing to their excellent bioavailability, high bioactivity, and low toxicity, selenium nanoparticles (SeNPs) are emerging nanomaterials. In this study, SeNPs with a size of ∼41.8 nm were synthesised by γ-irradiation using oligochitosan (OCS) as the stabiliser. As-synthesized SeNPs/OCS were characterised by UV-Vis spectroscopy, transmission electron microscopy, and energy-dispersive X-ray (EDX) analysis. Results revealed that the as-obtained SeNP/OCS powder exhibits high purity. The SeNP/OCS solution’s stability test results indicated that the SeNP/OCS solution stored at 4°C exhibits good stability for 60 days. The SeNP/OCS solution was unstable at ambient temperature, and SeNP/OCS exhibited agglomeration after about 15 days. SeNP/OCS products recovered the total white blood cells of γ-ray irradiated mice. The SeNP/OCS product, which was synthesised by a green approach, with high purity and efficient recuperation of white blood cells, can be used potentially as a functional supplement to assist cancer radiotherapy patients.
ISSN:2090-9063
2090-9071
DOI:10.1155/2021/6635022