Effect of portulaca oleracea (purslane) extract on inflammatory factors in nonalcoholic fatty liver disease: A randomized, double-blind clinical trial

• Published in: Journal of functional foods 2023-03, Vol.102, p.105465, Article 105465
• Main Authors: Darvish Damavandi, Reyhaneh, Shidfar, Farzad, Najafi, Mohammad, Janani, Leila, Masoodi, Mohsen, Heshmati, Javad, Ziaei, Somayeh
• Format: Article
• Language: English
• Subjects: Gene expression; GPx; NAFLD; NF-ƙB; Purslane
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2023.105465

[Display omitted] •Purslane is a traditional herbs which is known for its antioxidant and anti-inflammatory properties.•Purslane as an adjuvant therapy may improve inflammation and oxidative stress in NAFLD patients.•Effect of Purslane on oxidative stress and inflammatory markers needs more investigations. Non-alcoholic fatty liver disease (NAFLD) is one of the most serious liver disease that influences nearly-one-quarter of the worldwide adult population. Although the main mechanism of NAFLD is complex, several events can cause its progression such as oxidative stress, and inflammation. Recent studies have demonstrated useful effects of purslane intake on oxidative stress and inflammatory markers in NAFLD patients. To evaluate the efficacy and safety of purslane intake on nonalcoholic fatty liver disease we designed this study. We designed a randomized double-blinded clinical trial, and 74 patients with NAFLD were randomly assigned to intake either 300 mg purslane extract (n = 37) or placebo (n = 37) for 12 weeks. Outcome measures were nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ƙB), p65 nuclear activity, serum activity of glutathione peroxidase (GPx) and NF-ƙB p65 gene expression in peripheral blood mononuclear cells (PBMCs). The statistical analysis was performed by SPSS 22 and p value