Recent advances in anti-inflammation via AMPK activation

Inflammation is a complex physiological phenomenon, which is the body's defensive response, but abnormal inflammation can have adverse effects, and many diseases are related to the inflammatory response. AMPK, as a key sensor of cellular energy status, plays a crucial role in regulating cellula...

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Bibliographic Details
Published in:Heliyon 2024-07, Vol.10 (13), p.e33670, Article e33670
Main Authors: Xu, Yihua, Bai, Lan, Yang, Xinwei, Huang, Jianli, Wang, Jie, Wu, Xianbo, Shi, Jianyou
Format: Article
Language:English
Subjects:
AMPK
Inflammasome
Inflammation
NF-κB
Review
SIRT
Treatment
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Summary:Inflammation is a complex physiological phenomenon, which is the body's defensive response, but abnormal inflammation can have adverse effects, and many diseases are related to the inflammatory response. AMPK, as a key sensor of cellular energy status, plays a crucial role in regulating cellular energy homeostasis and glycolipid metabolism. In recent years, the anti-inflammation effect of AMPK and related signalling cascade has begun to enter everyone's field of vision – not least the impact on metabolic diseases. A great number of studies have shown that anti-inflammatory drugs work through AMPK and related pathways. Herein, this article summarises recent advances in compounds that show anti-inflammatory effects by activating AMPK and attempts to comment on them. The Signalling Pathways Associated with AMPK Activation & Compounds’ Anti-inflammatory Effect via AMPK Activation. [Display omitted]
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e33670