Preparation and Properties of Double-Crosslinked Hydroxyapatite Composite Hydrogels

Natural polymer hydrogels have good mechanical properties and biocompatibility. This study designed hydroxyapatite-enhanced photo-oxidized double-crosslinked hydrogels. Hyaluronic acid (HA) and gelatin (Gel) were modified with methacrylate anhydride. The catechin group was further introduced into th...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-09, Vol.23 (17), p.9962
Main Authors: Zhao, Benbo, Zhao, Mingda, Li, Liming, Sun, Shixiong, Yu, Heping, Cheng, Yuan, Yang, Yuedi, Fan, Yujiang, Sun, Yong
Format: Article
Language:English
Subjects:
Binding sites
Biocompatibility
Catechin
Cell adhesion & migration
Collagen
Crosslinking
dopamine
double crosslinked
Gelatin
Hyaluronic acid
Hydrocarbons
Hydrogels
Hydroxyapatite
hydroxyapatite-enhanced hydrogel
Marine chemistry
Mechanical properties
Molecular weight
Mussels
Natural polymers
Polymers
Stem cells
Stiffness
Structural stability
Tissue engineering
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Summary:Natural polymer hydrogels have good mechanical properties and biocompatibility. This study designed hydroxyapatite-enhanced photo-oxidized double-crosslinked hydrogels. Hyaluronic acid (HA) and gelatin (Gel) were modified with methacrylate anhydride. The catechin group was further introduced into the HA chain inspired by the adhesion chemistry of marine mussels. Hence, the double-crosslinked hydrogel (HG) was formed by the photo-crosslinking of double bonds and the oxidative-crosslinking of catechins. Moreover, hydroxyapatite was introduced into HG to form hydroxyapatite-enhanced hydrogels (HGH). The results indicate that, with an increase in crosslinking network density, the stiffness of hydrogels became higher; these hydrogels have more of a compact pore structure, their anti-degradation property is improved, and swelling property is reduced. The introduction of hydroxyapatite greatly improved the mechanical properties of hydrogels, but there is no change in the stability and crosslinking network structure of hydrogels. These inorganic phase-enhanced hydrogels were expected to be applied to tissue engineering scaffolds.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23179962