Iron Oxide Nanoparticles in Cancer Treatment: Cell Responses and the Potency to Improve Radiosensitivity

The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads to an increase in the potency of radiation therapy and allows for decreasing radiation dose and the concomitant side effects. Radiosensitization by metal oxide nanoparticles is widely...

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Bibliographic Details
Published in:Pharmaceutics 2023-09, Vol.15 (10), p.2406
Main Authors: Shestovskaya, Maria V, Luss, Anna L, Bezborodova, Olga A, Makarov, Valentin V, Keskinov, Anton A
Format: Article
Language:English
Subjects:
Antibodies
Biocompatibility
Brain cancer
Cancer
Cancer therapies
cancer treatment
Care and treatment
Cytotoxicity
Drug therapy
Ferric oxide
ionizing radiation
Iron
Iron compounds
iron oxide nanoparticles
iron reactivity
Kinases
Magnetic fields
Medical research
Nanoparticles
Peptides
Permeability
Physiology
Polyethylene glycol
Proteins
Radiation
radiosensitization
Radiotherapy
Review
Tumors
Vorinostat
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Summary:The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads to an increase in the potency of radiation therapy and allows for decreasing radiation dose and the concomitant side effects. Radiosensitization by metal oxide nanoparticles is widely discussed, but the range of mechanisms studied is not sufficiently codified and often does not reflect the ability of nanocarriers to have a specific impact on cells. This review is focused on the magnetic iron oxide nanoparticles while they occupied a special niche among the prospective radiosensitizers due to unique physicochemical characteristics and reactivity. We collected data about the possible molecular mechanisms underlying the radiosensitizing effects of iron oxide nanoparticles (IONPs) and the main approaches to increase their therapeutic efficacy by variable modifications.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15102406