Brain Natriuretic Peptides in Atherosclerotic Renal Artery Stenosis and Effects of Renal Angioplasty

Background: We hypothesized that plasma levels of brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) would be elevated, and adiponectin concentrations reduced, in patients with atherosclerotic renal artery stenosis (ARAS) and that BNPs might be used to identify patients who would ben...

Full description

Saved in:
Bibliographic Details
Published in:Kidney & blood pressure research 2013-01, Vol.37 (6), p.657-666
Main Authors: Nowakowska-Fortuna, Elzbieta, Saeed, Aso, Guron, Gregor, Fu, Michael, Hammarsten, Ola, Jensen, Gert, Herlitz, Hans
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - antagonists & inhibitors
Adiponectin - blood
Aged
Angioplasty - methods
Atherosclerosis - blood
Atherosclerosis - diagnostic imaging
Atherosclerosis - therapy
Biomarkers - blood
Brain natriuretic peptide
Brain natriuretic peptide Renal angioplasty
Clinical Medicine
Female
Humans
Klinisk medicin
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Original Paper
Radiography
Renal angioplasty
Renal Artery - diagnostic imaging
Renal Artery Obstruction - blood
Renal Artery Obstruction - diagnostic imaging
Renal Artery Obstruction - therapy
Renal artery stenosis
Renovascular hypertension
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: We hypothesized that plasma levels of brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) would be elevated, and adiponectin concentrations reduced, in patients with atherosclerotic renal artery stenosis (ARAS) and that BNPs might be used to identify patients who would benefit from percutaneous transluminal renal angioplasty (PTRA). Methods: Data were collected before renal angiography in 91 patients with hypertension and suspected ARAS (significant ARAS; n=47, and non-RAS; n=44) and in 20 healthy controls (C). In ARAS patients analyses were repeated four weeks after PTRA. Results: Ambulatory systolic blood pressure (ASBP) was significantly elevated in the ARAS group vs. both C and non-RAS groups. Baseline plasma BNP and NT-proBNP levels were significantly elevated, and adiponectin concentrations reduced, in the ARAS group vs. C but not vs. the non-RAS group. One month after PTRA, ASBP was reduced vs. baseline (149±16 to 139±15 mm p
ISSN:1420-4096
1423-0143
DOI:10.1159/000355746