An Updated View on the Rck Invasin of Salmonella : Still Much to Discover

• Published in: Frontiers in cellular and infection microbiology 2017-12, Vol.7, p.500-500
• Main Authors: Mambu, Julien, Virlogeux-Payant, Isabelle, Holbert, Sébastien, Grépinet, Olivier, Velge, Philippe, Wiedemann, Agnès
• Format: Article
• Language: English
• Subjects: Adhesins, Bacterial - metabolism; Bacterial Adhesion; bacterial internalization; cell signaling; Endocytosis; ErbB Receptors - metabolism; gene expression; Gene Expression Regulation, Bacterial; Life Sciences; membrane receptor; Microbiology; Microbiology and Parasitology; outer membrane protein; Protein Binding; Salmonella; Salmonella - physiology; Salmonella Infections - microbiology; Type III Secretion Systems - metabolism
• ISSN: 2235-2988; 2235-2988
• DOI: 10.3389/fcimb.2017.00500

is a facultative intracellular Gram-negative bacterium, responsible for a wide range of food- and water-borne diseases ranging from gastroenteritis to typhoid fever depending on hosts and serotypes. thus represents a major threat to public health. A key step in pathogenesis is the invasion of phagocytic and non-phagocytic host cells. To trigger its own internalization into non-phagocytic cells, has developed different mechanisms, involving several invasion factors. For decades, it was accepted that could only enter cells through a type three secretion system, called T3SS-1. Recent research has shown that this bacterium expresses outer membrane proteins, such as the Rck protein, which is able to induce entry mechanism. Rck mimics natural host cell ligands and triggers engulfment of the bacterium by interacting with the epidermal growth factor receptor. is thus able to use multiple entry pathways during the infection process. However, it is unclear how and when exploits the T3SS-1 and Rck entry mechanisms. As a series of reviews have focused on the T3SS-1, this review aims to describe the current knowledge and the limitations of our understanding of the Rck outer membrane protein. The regulatory cascade which controls Rck expression and the molecular mechanisms underlying Rck-mediated invasion into cells are summarized. The potential role of Rck-mediated invasion in pathogenesis and the intracellular behavior of the bacteria following a Rck-dependent entry are discussed.