Potential SARS-CoV-2 Preimmune IgM Epitopes

While studying the human public IgM igome as represented by a library of 224,087 linear mimotopes, three exact matches to peptides in the proteins of SARS-CoV-2 were found: two in the open reading frame 1ab and one in the spike protein. Joining the efforts to fast track SARS-CoV-2 vaccine developmen...

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Bibliographic Details
Published in:Frontiers in immunology 2020-04, Vol.11, p.932-932
Main Authors: Shivarov, Velizar, Petrov, Peter K, Pashov, Anastas D
Format: Article
Language:English
Subjects:
Antibodies, Viral - chemistry
Antibodies, Viral - immunology
B cell precursors
Betacoronavirus - immunology
epitope
Epitopes - chemistry
Humans
IgM
Immunoglobulin M - chemistry
Immunoglobulin M - immunology
Immunology
mimotope
Peptides - chemistry
Peptides - immunology
SARS-CoV-2
Spike Glycoprotein, Coronavirus - chemistry
Spike Glycoprotein, Coronavirus - immunology
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Summary:While studying the human public IgM igome as represented by a library of 224,087 linear mimotopes, three exact matches to peptides in the proteins of SARS-CoV-2 were found: two in the open reading frame 1ab and one in the spike protein. Joining the efforts to fast track SARS-CoV-2 vaccine development, here we describe briefly these potential epitopes in comparison to mimotopes representing peptides of SARS-CoV, HCoV 229E and OC43.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.00932