Innate Immunity Stimulation during the COVID-19 Pandemic: Challenge by Parvulan

Aim. We report an open spontaneous anecdotical retrospective survey of Corynebacterium parvum administration to 4000 fragile immune-depressed and multimorbid patients treated with a killed C. parvum strain to enhance innate immunity, integrating the adaptative immune response for long-standing antin...

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Bibliographic Details
Published in:Journal of immunology research 2022-04, Vol.2022, p.4593598-9
Main Authors: Palmieri, Beniamino, Manenti, Antonio, Galotti, Francesca, Vadalà, Maria
Format: Article
Language:English
Subjects:
Adaptive immunity
Antibodies
Cancer
Cell number
Chronic illnesses
Clinical trials
Coronaviruses
COVID-19
Disease
Drug dosages
Female
Fungal infections
Humans
Immune response
Immune system
Immunity, Innate
Immunology
Immunosuppressive agents
Innate immunity
Lymphocytes
Male
Neuralgia
Pandemics
Patients
Prostatitis
Quality control
Quality of life
Questionnaires
Retrospective Studies
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
Steroid hormones
Treatment Outcome
Viral infections
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Summary:Aim. We report an open spontaneous anecdotical retrospective survey of Corynebacterium parvum administration to 4000 fragile immune-depressed and multimorbid patients treated with a killed C. parvum strain to enhance innate immunity, integrating the adaptative immune response for long-standing antinfectious resistance. Methods. A total of 4000 patients (1900 men and 2100 women) with mild, moderate, or chronic disease, appealing to our Second Opinion Medical Consultation Network, signed an informed consent form and were injected subcutaneously with C. parvum. The treatment was followed up to 6 months, completing the short form of the medical outcome health survey questionnaire (SF-36) directly by the patients or their parents and monitoring their health status regularly via telemedicine (Skype, WhatsApp, mail, etc.) or outpatients visits. Results. The main efficacy endpoints, as assessed by the SF-36 questionnaire are: significant improvements in the mental and physical role functioning score (p
ISSN:2314-8861
2314-7156
DOI:10.1155/2022/4593598