Esophageal Melanocytosis

Esophageal melanocytosis is a rare entity defined by the proliferation of a melanocytic basal layer of the esophageal squamous lining and deposition of melanin in the esophageal mucosa. Esophageal melanocytosis is considered a benign entity of unknown etiology; however, it has been reported as a mel...

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Bibliographic Details
Published in:Autopsy & case reports 2024, Vol.14, p.e2024487-e2024487
Main Authors: Thapa, Samikshya, Yadav, Gajendra Kumar, Mondal, Ratna, Phulware, Ravi Hari
Format: Article
Language:English
Subjects:
ANATOMY & MORPHOLOGY
Clinical Case Report
Endoscopy, Gastrointestinal
Esophageal Mucosa
Esophagus
Gastroesophageal Reflux
Melanins
PATHOLOGY
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Summary:Esophageal melanocytosis is a rare entity defined by the proliferation of a melanocytic basal layer of the esophageal squamous lining and deposition of melanin in the esophageal mucosa. Esophageal melanocytosis is considered a benign entity of unknown etiology; however, it has been reported as a melanoma precursor. We report a case of esophageal melanocytosis in a diabetic and hypertensive 67-year-old male with recurrent dizziness and syncope for the past 6 months. Given his complaint of dyspepsia, he underwent an upper gastrointestinal endoscopy, in which an esophageal biopsy revealed the diagnosis of esophageal melanocytosis. The definitive diagnosis of esophageal melanocytosis can only be made by histological analysis. The histologic differential diagnoses include melanocytic nevi and malignant melanoma. Therefore, they need to be ruled out.
ISSN:2236-1960
2236-1960
DOI:10.4322/acr.2024.487