Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice

We have investigated the antinociceptive effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) in two classical models of pain in male Swiss mice (25-35 g), the writhing test and the formalin test. At doses of 30, 100 and 300 mg/kg (po), EOOG produced a dose-dependent inhibition (f...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 2003-04, Vol.36 (4), p.521-524
Main Authors: Rabelo, M, Souza, E P, Soares, P M G, Miranda, A V, Matos, F J A, Criddle, D N
Format: Article
Language:English
Subjects:
Analgesics - pharmacology
Animals
Antinociception
BIOLOGY
Essential oil
Labiatae
Male
MEDICINE, RESEARCH & EXPERIMENTAL
Mice
Ocimum
Ocimum gratissimum L
Oils, Volatile - pharmacology
Pain Measurement - drug effects
Phytotherapy
Plant Oils - therapeutic use
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Summary:We have investigated the antinociceptive effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) in two classical models of pain in male Swiss mice (25-35 g), the writhing test and the formalin test. At doses of 30, 100 and 300 mg/kg (po), EOOG produced a dose-dependent inhibition (from 58.3 4.4 to 40.7 6.3, 36.4 3.6 and 24.6 3.6, respectively; N = 8-10, P
ISSN:0100-879X
1414-431X
0100-879X
1414-431X
DOI:10.1590/s0100-879x2003000400016