miRNAs Regulation and Its Role as Biomarkers in Endometriosis

MicroRNAs (miRNAs) are small non-coding RNAs (18-22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of d...

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Bibliographic Details
Published in:International Journal of Molecular Sciences 2016-01, Vol.17 (1), p.93-93
Main Authors: Marí-Alexandre, Josep, Sánchez-Izquierdo, Dolors, Gilabert-Estellés, Juan, Barceló-Molina, Moisés, Braza-Boïls, Aitana, Sandoval, Juan
Format: Article
Language:English
Subjects:
biomarker
Biomarkers
Biomarkers - blood
Endometriosis
Endometriosis - blood
Endometriosis - diagnosis
Endometriosis - genetics
Endometriosis - pathology
Endometrium - metabolism
Endometrium - pathology
Female
Gene Expression Regulation
Humans
microRNA
MicroRNAs - blood
MicroRNAs - genetics
non-coding RNA
Review
Ribonucleic acid
RNA
RNA, Messenger - blood
RNA, Messenger - genetics
RNA, Small Cytoplasmic - blood
RNA, Small Cytoplasmic - genetics
RNA, Small Interfering - blood
RNA, Small Interfering - genetics
RNA, Transfer - blood
RNA, Transfer - genetics
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Summary:MicroRNAs (miRNAs) are small non-coding RNAs (18-22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of deep-sequencing technologies. New biogenesis pathways and sources of miRNAs are changing our concept about these molecules. The study of the miRNA contribution to pathological states is a field of great interest in research. Different groups have reported the implication of miRNAs in pathologies such as cancer, diabetes, cardiovascular, and gynecological diseases. It is also well-known that miRNAs are present in biofluids (plasma, serum, urine, semen, and menstrual blood) and have been proposed as ideal candidates as disease biomarkers. The goal of this review is to highlight the current knowledge in the field of miRNAs with a special emphasis to their role in endometriosis and the newest investigations addressing the use of miRNAs as biomarkers for this gynecological disease.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms17010093