Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains

Seasonal influenza vaccine formulas change almost every year yet information about how this affects the antibody repertoire of vaccine recipients is inadequate. New vaccine virus strains are selected, replacing older strains to better match the currently circulating strains. But even while the vacci...

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Bibliographic Details
Published in:Scientific reports 2017-07, Vol.7 (1), p.5258-12, Article 5258
Main Authors: Plant, Ewan P., Fredell, Lucy J., Hatcher, Blake A., Li, Xing, Chiang, Meng-Jung, Kosikova, Martina, Xie, Hang, Zoueva, Olga, Cost, Angelia A., Ye, Zhiping, Cooper, Michael J.
Format: Article
Language:English
Subjects:
631/250/590/1883
631/326/596/1578
692/308/409
Antibody response
Epitopes
Hemagglutination inhibition
Humanities and Social Sciences
Immunization
Influenza
Influenza A
multidisciplinary
Science
Science (multidisciplinary)
Strains (organisms)
Vaccines
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Summary:Seasonal influenza vaccine formulas change almost every year yet information about how this affects the antibody repertoire of vaccine recipients is inadequate. New vaccine virus strains are selected, replacing older strains to better match the currently circulating strains. But even while the vaccine is being manufactured the circulating strains can evolve. The ideal response to a seasonal vaccine would maintain antibodies toward existing strains that might continue to circulate, and to generate cross-reactive antibodies, particularly towards conserved influenza epitopes, potentially limiting infections caused by newly evolving strains. Here we use the hemagglutination inhibition assay to analyze the antibody repertoire in subjects vaccinated two years in a row with either identical vaccine virus strains or with differing vaccine virus strains. The data indicates that changing the vaccine formulation results in an antibody repertoire that is better able to react with strains emerging after the vaccine virus strains are selected. The effect is observed for both influenza A and B strains in groups of subjects vaccinated in three different seasons. Analyses include stratification by age and sex.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-05579-4