Association of cystatin C levels with metabolic syndrome incidence: a nested case-control study with propensity score matching

Objective Metabolic syndrome (MetS) involves multiple metabolic disorders and seriously affects human health. Identification of key biological factors associated with MetS incidence is therefore important. We explored the association between MetS and the biochemical profiles of Chinese adults in She...

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Bibliographic Details
Published in:Journal of international medical research 2021-01, Vol.49 (1), p.300060520986311-300060520986311
Main Authors: Yang, Tengfei, Pei, Dongmei
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Case-Control Studies
Cystatin C
Humans
Metabolic syndrome
Metabolic Syndrome - diagnosis
Metabolic Syndrome - epidemiology
Propensity Score
Retrospective Clinical Research Report
Risk Factors
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Summary:Objective Metabolic syndrome (MetS) involves multiple metabolic disorders and seriously affects human health. Identification of key biological factors associated with MetS incidence is therefore important. We explored the association between MetS and the biochemical profiles of Chinese adults in Shenyang City in a nested case-control study. Methods We included adult participants who underwent physical examination at our hospital for 2 consecutive years. Participants’ biochemical profiles and other MetS components were tested and monitored continuously. Propensity score matching was used to adjust confounding factors between participants with and without MetS. We analyzed the association between incidence of MetS and the biochemical profiles of participants. Results Of 5702 participants who underwent physical examination between 1 January 2017 and 1 December 2018, 538 had confirmed newly developed MetS. After successfully matching 436 pairs of participants, mean cystatin C (Cys-C) level was significantly higher in the MetS group than in the non-MetS group. Logistic regression analysis indicated that age (years) and γ-glutamate transpeptidase, creatinine, uric acid, and Cys-C levels were significantly associated with MetS incidence; among these, the odds ratio of Cys-C was highest (3.03; 95% confidence interval, 1.02–9.00). Conclusions Cys-C levels were significantly associated with the incidence of MetS among Chinese adults.
ISSN:0300-0605
1473-2300
DOI:10.1177/0300060520986311